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Neuroprotective effects of Apigenin on prenatal Valproic acid-induced autism spectrum disorder in rats.
IBRO Neurosci Rep
December 2024
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Unlabelled: Valproic acid (VPA) demonstrates teratogenic effects during pregnancy. Prenatal exposure to VPA may result in autism spectrum disorder (ASD) -like phenotypes. Apigenin, a natural flavonoid, has been shown to have neuroprotective impacts due to its antioxidant properties.
View Article and Find Full Text PDFIncreased Serotonin Levels and Unchanged Glutamate and GABA Levels in Thalamic Microdialysates Despite Reduced Cell Numbers in a Valproic Acid-Induced Autism Model.
Neurochem Res
December 2024
School of Medicine, Department of Physiology, Eskisehir Osmangazi University, Eskisehir, 26040, Turkey.
Article Synopsis
- Autism spectrum disorders (ASDs) are neurodevelopmental conditions marked by social skill deficits and abnormal sensory responses, with an imbalance of excitation and inhibition in the brain being a crucial factor.
- This study examined the levels of key neurotransmitters (GABA, glutamate, and serotonin) in the thalamus of rats induced with ASD using valproic acid (VPA) during pregnancy.
- Results showed that ASD rats had higher serotonin levels, altered thalamic volumes, and fewer thalamic neurons and glia compared to the control group, suggesting a disrupted neurotransmitter balance in the thalamus related to ASD.
Risk factors and a nomogram for predicting valproic acid-induced liver injury : A nested case-control study.
Biomol Biomed
November 2024
School of Pharmacy, Anhui Medical University, Hefei, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China.
The risk factors for liver injury induced by valproic acid (VPA) are not well understood, and no predictive tool currently exists to identify patients at risk. This study aims to explore these risk factors and develop a predictive model. We collected medical data from patients treated with VPA between January 1, 2020, and October 31, 2023.
View Article and Find Full Text PDFLipopolysaccharide induces neuroinflammation in a valproic acid male model of autism.
Brain Res Bull
January 2025
Department of Pediatrics, The first Affiliated Hospital of Anhui Medical University, Hefei, Anhui, PR China; Beijing Children's Hospital, Capital Medical University, China National Clinical Research Center of Respiratory Diseases, Beijing, PR China. Electronic address:
Background: Autism spectrum disorders (ASD) are characterized by social skill deficits and behavior impairments. Exposure to valproic acid (VPA) has been linked to ASD in humans and ASD-like behaviors in rodents. Clinical evidence suggests that immunological damage can worsen ASD symptoms in humans.
View Article and Find Full Text PDFAmeliorative effects of Edaravone against Valproic Acid-Induced kidney damage.
J Mol Histol
November 2024
Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpaşa, 34320, Avcilar-Istanbul, Türkiye.
Valproic acid (VPA) is a well-known and increasingly documented antiepileptic drug that has been widely used in the treatment of epilepsy and/or epilepsy-related disorders. Prolonged clinical use of VPA has been reported to cause side effects such as nephrotoxicity. Edaravone (EDA) is a powerful free radical scavenger.
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