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DECORIN, a triceps-derived myokine, protects sorted β-cells and human islets against chronic inflammation associated with type 2 diabetes.
Acta Physiol (Oxf)
February 2025
UR Diabète et Thérapeutiques, Centre européen d'étude du Diabète, Université de Strasbourg, Strasbourg, France.
Aim: Pancreatic β-cells are susceptible to inflammation, leading to decreased insulin production/secretion and cell death. Previously, we have identified a novel triceps-derived myokine, DECORIN, which plays a pivotal role in skeletal muscle-to-pancreas interorgan communication. However, whether DECORIN can directly impact β-cell function and susceptibility to inflammation remains unexplored.
View Article and Find Full Text PDFExercise and exerkines: Mechanisms and roles in anti-aging and disease prevention.
Exp Gerontol
January 2025
Shanghai anti-doping Laboratory, Shanghai University of Sport, Shanghai 200438, China; Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. These bioactive molecules, which include hepatokines, myokines, adipokines, osteokines, and neurokines, act both locally and systemically to exert protective effects against the detrimental aspects of aging.
View Article and Find Full Text PDFMuscle-brain crosstalk mediated by exercise-induced myokines - insights from experimental studies.
Front Physiol
December 2024
Laboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, Academy of Physical Education, Katowice, Poland.
Over the past couple of decades, it has become apparent that skeletal muscles might be engaged in endocrine signaling, mostly as a result of exercise or physical activity in general. The importance of this phenomenon is currently studied in terms of the impact that exercise- or physical activity -induced signaling factors have, in the interaction of the "muscle-brain crosstalk." So far, skeletal muscle-derived myokines were demonstrated to intercede in the connection between muscles and a plethora of various organs such as adipose tissue, liver, or pancreas.
View Article and Find Full Text PDFPoor bone health in Duchenne muscular dystrophy: a multifactorial problem beyond corticosteroids and loss of ambulation.
Front Endocrinol (Lausanne)
December 2024
Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, United States.
Duchenne muscular dystrophy (DMD) is a progressive, fatal muscle wasting disease caused by X-linked mutations in the dystrophin gene. Alongside the characteristic muscle weakness, patients face a myriad of skeletal complications, including osteoporosis/osteopenia, high susceptibility to vertebral and long bone fractures, fat embolism post-fracture, scoliosis, and growth retardation. Those skeletal abnormalities significantly compromise quality of life and are sometimes life-threatening.
View Article and Find Full Text PDFThe Influence of Physical Training on Breast Cancer: The Role of Exercise-Induced Myokines in Regulating Breast Cancer Cell Growth and Survival.
Int J Mol Sci
October 2024
Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Article Synopsis
- Physical training is known to lower cancer risk, and it’s suggested that myokines released by skeletal muscle have an anti-tumor effect, but more research is needed, particularly in breast cancer patients.
- A study involving 12 weeks of resistance training with whole-body electromyostimulation (WB-EMS) showed improvements in physical performance and muscle mass in breast cancer patients, along with their blood serum inhibiting cancer cell growth in lab tests.
- The research highlights that myokines, like CXCL1, IL10, and CCL4, can enhance the death of cancer cells, indicating the potential for physical exercise to be a supportive therapy in breast
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