Background: Natalizumab, a treatment used in multiple sclerosis (MS), is associated with cases of progressive multifocal leukoencephalopathy (PML).
Objective: We describe two cases of PML in related but not genetically apparented natalizumab-treated MS patients who are stepsisters. Reported cases/outcomes: While Patient 1 developed PML, Patient 2 was on natalizumab and had contacts with Patient 1. Patient 2 was diagnosed with PML 5 months after Patient 1.
Conclusion: The clinical and temporal data highly suggest that there was JC virus (JCV) transmission from one patient to the other with development of PML as primo-infection in Patient 2.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/1352458516670734 | DOI Listing |
Publication Analysis
Top Keywords
progressive multifocal
8
multifocal leukoencephalopathy
8
patient
7
leukoencephalopathy natalizumab-treated
4
natalizumab-treated stepsisters
4
stepsisters intriguing
4
intriguing coincidence
4
coincidence background
4
background natalizumab
4
natalizumab treatment
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!