Sleep disorders and occupational hazards, injuries, and illnesses impact an individual's overall health. In the United States, substantial racial, ethnic, and socioeconomic disparities exist in sleep and occupational health. Primary care physicians working in underserved communities should be aware of this disparity and target these higher-risk populations for focused evaluation and intervention.
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Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity.
Environ Int
December 2024
Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:
Aristolochic Acid I (AAI) is widely present in traditional Chinese medicines derived from the Aristolochia genus and is known to cause significant damage to renal tubular epithelial cells. Genome-wide screening has proven to be a powerful tool in identifying critical genes associated with the toxicity of exogenous substances. To identify undiscovered key genes involved in AAI-induced renal toxicity, a genome-wide CRISPR library screen was conducted in the human kidney-2 (HK-2) cell line.
View Article and Find Full Text PDFON THE ISSUE OF RADON EXPOSURE IN THE EXISTING RADIATION SITUATION AT WORKPLACES.
Probl Radiac Med Radiobiol
December 2024
State Institution «O.M. Marzіeiev Institute for Public Health of the National Academy of Medical Sciences of Ukraine», 50 Hetman Pavlo Polubotok Str., Kyiv, 02094, Ukraine.
Objective: assessment of probable exposure levels from radon and NORM in workplaces within the context of justi fying radiation protection plans in an existing exposure situation.
Materials And Methods: Materials regarding the assessment of naturally occurring radioactive material (NORM) con tent in tailing from mining and processing industries in Ukraine and assessments of contamination levels of industri al sites of oil and gas enterprises were used for estimating the probable range of effective doses (ED) of workers fromNORM at industrial enterprises. These materials were obtained as a result of research conducted by specialists from theRadiation Protection Laboratory of the State Institution «O.
Discordant Information on Blinding in Trial Registries and Published Research: A Systematic Review.
JAMA Netw Open
December 2024
School of Management, Shanxi Medical University, Taiyuan, China.
Importance: Blinding of individuals involved in randomized clinical trials (RCTs) can be used to protect against performance and biases, but discrepancies in the reporting of methodological features between registered protocols and subsequent trial publications may lead to inconsistencies, thereby reintroducing bias.
Objective: To investigate inconsistency in blinding as reported in trial registries and publications.
Data Sources: An exploratory dataset and a validation dataset were created.
Squaraine dye as a fluorescent probe for highly sensitive detection of pyrophosphate and alkaline phosphatase.
Anal Sci
December 2024
NHC Key Laboratory for Engineering Control of Dust Hazard, National Center for Occupational Safety and Healthy, NHC, Beijing, 102308, China.
We synthesized a squaraine dye (F-0) to develop a method for detecting pyrophosphate (PPi) and alkaline phosphatase (ALP) by modulating the fluorescence of F-0. The fluorescence intensity of the F-0 system was quenched upon the addition of Cu ions; however, it was restored when PPi was introduced due to the formation of a complex between PPi and Cu. Since ALP can hydrolyze PPi, the fluorescence of the system was quenched again upon the addition of ALP.
View Article and Find Full Text PDFPsychosocial work stressors and mental health in Ph.D. students in Germany-Evidence from two cross-sectional samples.
PLoS One
December 2024
Institute of Occupational, Social, and Environmental Medicine, Centre for Health and Society, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Background: Ph.D. students have been shown to report a lower mental health status compared to the general population.
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