There is increasing interest in the construct validity of higher-order domains of the Big Five personality traits. A total of 831 persons from the Swiss population completed the International Personality Item Pool and an adaptation of the Positive and Negative Affect Scales. Using Goldberg's bass-ackwards method, we found evidence for the general factor of personality (GFP) and the two meta-traits of positive emotionality (blend of low neuroticism and high extraversion) and constraint (blend of high agreeableness and conscientiousness). In association with positive affect, the explanatory power of the GFP (r = 0.43) and positive emotionality (r = 0.37) was largely superior to extraversion (r = 0.24), conscientiousness (r = 0.18), agreeableness (r = 0.09) and openness (r = 0.04), although not neuroticism (r = -0.34). In association with negative affect, neuroticism (r = 0.41), the GFP (r = -0.36) and positive emotionality (r = -0.35) were the most powerful single predictors. We conclude that the higher-order structure of personality is best explained by the meta-traits of positive emotionality and constraint, which correspond closely to the well-established superfactors of internalizing and externalizing. We further demonstrate that these have substantial criterion validity when broad positive and negative affect is the outcome of interest. These findings help to relate Big Five meta-traits to pathological personality. Copyright © 2017 John Wiley & Sons, Ltd.
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December 2024
Interventional Oncology, Johnson & Johnson Enterprise Innovation, Inc, 10th Floor 255 Main St, 02142, Cambridge, Boston, MA, USA.
The introduction of anti-PD-1/PD-L1 therapies revolutionized treatment for advanced non-small cell lung cancer (NSCLC), yet response rates remain modest, underscoring the need for predictive biomarkers. While a T cell inflamed gene expression profile (GEP) has predicted anti-PD-1 response in various cancers, it failed in a large NSCLC cohort from the Stand Up To Cancer-Mark (SU2C-MARK) Foundation. Re-analysis revealed that while the T cell inflamed GEP alone was not predictive, its performance improved significantly when combined with gene signatures of myeloid cell markers.
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December 2024
Department of Health Management, Chronic Health Management Laboratory, Henan Provincial People's Hospital, Zhengzhou, 450003, China.
Despite numerous studies investigating the correlation between the serum uric acid and high-density lipoprotein cholesterol ratio (UHR) and fatty liver disease, the evidence for the dose-response relationship between UHR and liver fat content (LFC) remains uncertain. This study employs quantitative computed tomography (CT) to quantify LFC and aims to investigate the correlation and dose-response relationship between UHR levels and LFC in Chinese adults. Based on the health check-up data from 2021 at Henan Provincial People's Hospital, China, the objective of this cross-sectional study was to investigate the association between UHR levels and LFC among individuals of different genders.
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December 2024
Affiliated Hospital of Jiangnan University, Wuxi, 214000, Jiangsu, China.
Vitamin D is crucial for maintaining bone health and development, and bone mineral accumulation during childhood and adolescence affects long-term bone health. Vitamin D deficiency has been widely recognized as one of the main causes of osteoporosis and fractures, especially during the growth and development stage of children. Recent studies have shown that vitamin D deficiency may affect the deviation of bone development in children by mediating lipid metabolism disorders, but its specific mechanism of action has not been fully elucidated.
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December 2024
Institute for Advanced Study, Technical University of Munich, 85748, Garching, Germany.
We examined how urban environments affect the abundance, proportion, and diversity of plumage color morphs in feral pigeons. Five major plumage color morphs (black, blue, white, red, and mixed) were counted in sixty 25-ha plots in Poznań City (Poland). Generalized additive models were used to study the correlations among abundance, proportion of morphs, and environmental factors.
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December 2024
Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Heat stress (HS) is an impactful condition in ruminants that negatively affects their physiological and rumen microbial composition. However, a fundamental understanding of metabolomic and metataxonomic mechanisms in goats under HS conditions is lacking. Here, we analyzed the rumen metabolomics, metataxonomics, and serum metabolomics of goats (n = 10, body weight: 41.
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