AI Article Synopsis
- The study aimed to explore the relationship between brachial artery flow-mediated dilation (FMD) and specific serum biomarkers linked to endothelial function, particularly during cardiopulmonary bypass (CPB) surgery.
- Researchers used sonography to measure changes in brachial artery size and analyzed the levels of endothelial biomarkers like endothelin 1 and nitric oxide in 27 patients undergoing CPB.
- Results revealed significant changes in biomarkers during CPB, with a notable negative correlation between FMD and von Willebrand factor, suggesting that sonographic assessment can effectively identify acute endothelial injury in cardiac surgery patients.
Article Abstract
Objectives: The purpose of this study was to investigate the correlation between flow-mediated dilatation of the brachial artery and serum endothelial biomarkers and to discuss the feasibility of sonographic evaluation of acute endothelial injury during cardiopulmonary bypass (CPB) surgery.
Methods: Sonography was applied to determine the percentage of change in the brachial artery size during flow-mediated dilatation. Meanwhile, the plasma concentrations of endothelial-derived biomarkers, such as endothelin 1, nitric oxide, and von Willebrand factor, were measured to monitor the changes in endothelial function. We analyzed the correlation between flow-mediated dilatation and biomarkers during the perioperative period of CPB in 27 patients.
Results: All of the biomarkers changed dramatically, especially during the CPB period. There was a negative correlation between flow-mediated dilatation and von Willebrand factor (P = .001; R = -0.31).
Conclusions: A CPB event has a substantial impact on endothelial function, and sonographic assessment of the percentage of change in the brachial artery size during flow-mediated dilatation allows early detection of acute endothelial function injury in cardiac surgery.
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| http://dx.doi.org/10.7863/ultra.16.02071 | DOI Listing |
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