AI Article Synopsis
- - The study focused on how fungal structure and aeration processes influence the growth and production of microbial oil rich in arachidonic acid (ARA).
- - A multi-stage fermentation strategy that coordinated fed-batch culture with controlled aeration and agitation significantly improved yields, achieving a final dry cell weight of 41.4 g/L, lipid yield of 22.2 g/L, and ARA yield of 13.5 g/L, all surpassing traditional methods.
- - The research demonstrates that transforming fungal morphology from pellet-like to rice-shaped enhances oxygen transfer, which is crucial for efficient biomass accumulation and ARA oil production on an industrial scale.
Article Abstract
Background: Fungal morphology and aeration play a significant role in the growth process of . The production of microbial oil rich in arachidonic acid (ARA) in was enhanced by using a multi-stage fermentation strategy which combined fed-batch culture with precise control of aeration and agitation rates at proper times.
Results: The fermentation period was divided into four stages according to the cultivation characteristics of . The dissolved oxygen concentration was well suited for ARA biosynthesis. Moreover, the ultimate dry cell weight (DCW), lipid, and ARA yields obtained using this strategy reached 41.4, 22.2, 13.5 g/L, respectively. The respective values represent 14.8, 25.8, and 7.8% improvements over traditional fed-batch fermentation processes.
Conclusions: This strategy provides promising control insights for the mass production of ARA-rich oil on an industrial scale. Pellet-like fungal morphology was transformed into rice-shaped particles which were beneficial for oxygen transfer and thus highly suitable for biomass accumulation.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243910 | PMC |
| http://dx.doi.org/10.1186/s40643-017-0138-8 | DOI Listing |
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