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| http://dx.doi.org/10.4103/0974-2077.197091 | DOI Listing |
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Long oligos: direct chemical synthesis of genes with up to 1728 nucleotides.
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Department of Chemistry,, and Health Research Institute, Michigan Technological University Houghton Michigan 49931 USA
The longest oligos that can be chemically synthesized are considered to be 200-mers. Here, we report direct synthesis of an 800-mer green fluorescent protein gene and a 1728-mer 29 DNA polymerase gene on an automated synthesizer. Key innovations that enabled this breakthrough include conducting the synthesis on a smooth surface rather than within the pores of traditional supports, and the use of the powerful catching-by-polymerization (CBP) method for isolating the full-length oligos from a complex mixture.
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School of Chemical and Biotechnology, SASTRA University, Thanjavur, 613401 Tamil Nadu India.
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Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
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