To investigate the clinical and genetic characteristics of 5 pedigrees of Gitelman syndrome (GS), and summarize its advances in genetics, diagnosis and management. Five families with GS were identified and total genome DNA were extracted from the peripheral blood of all the family members. The exons and their flanking introns of gene were amplified by PCR and screened for mutation using Autoassembler 2.0 software. Six heterozygous gene mutations were found in the five pedigrees, including two complex combination of deletion and insertion mutation (c.486-490delTACGGinsA and c. 965-1_969delgCGGACinsACCGAAA and c. 976-977delGT). These mutations were predicted to change the normal protein structure. These 6 mutations are the major cause of the five pedigrees of GS.
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| http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2017.02.005 | DOI Listing |
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