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(1, 3)-beta-D-Glucan in bronchoalveolar lavage fluid: a useful biomarker in diagnosis of invasive pulmonary infection caused by Hormographiella aspergillata?
Diagn Pathol
December 2024
Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China.
Hormographiella aspergillata is a rare hyaline mold causing invasive fungal infection in humans, until the frequent use of antifungal prophylaxis in immunocompromised hosts. Due to the high mortality of H. aspergillata infection, early recognition and treatment are crucial.
View Article and Find Full Text PDFCase report: Unveiling the silent threat in the ICU - a case of disseminated invasive aspergillosis in a patient with fulminant myocarditis.
Front Immunol
December 2024
Fourth Department of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
Invasive aspergillosis (IA) significantly increases mortality in critically ill patients in the ICU and its occurrence is closely related to immunocompromise. Dissemination of IA is easily misdiagnosed and mistreated due to its ability to invade multiple systems throughout the body and lack of typical clinical manifestations. In this case, a 25-year-old previously healthy woman was hospitalized with fulminant myocarditis and treated with veno-arterial extracorporeal membrane pulmonary oxygenation (VA-ECMO) support and intravenous acyclovir, high-dose methylprednisolone, and immunoglobulin.
View Article and Find Full Text PDFMusculoskeletal manifestations of lower-extremity coccidioidomycosis: a case series.
J Bone Jt Infect
July 2024
Valley Fever Center for Excellence, College of Medicine - Tucson, University of Arizona, Tucson, AZ, United States of America.
Article Synopsis
- Coccidioidomycosis is a fungal infection common in the southwestern U.S. that can affect the musculoskeletal system, particularly in serious cases, though lower extremity involvement is less frequently documented.
- The study highlighted three cases from southern Arizona showcasing different manifestations of lower extremity osteoarticular coccidioidomycosis, each with distinct clinical challenges and treatment approaches.
- Effective treatment typically involves surgical debridement and extended antifungal therapy, emphasizing the need for careful diagnosis as the symptoms often resemble non-infectious conditions.
Genetic microevolution of clinical with reduced Amphotericin B sensitivity in China.
Emerg Microbes Infect
December 2024
National Clinical Research Center for Laboratory Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Department of Laboratory Medicine, the First Hospital of China Medical University, Shenyang, People's Republic of China.
The global rate of Amphotericin B (AmB) resistance in has surpassed 12%. However, there is limited data on available clinical treatments and microevolutionary analyses concerning reduced AmB sensitivity. In this study, we collected 18 isolates from five patients between 2019 and 2022.
View Article and Find Full Text PDFObstructive Bilateral Renal Fungal Bezoars in an Extremely Premature Neonate Treated With Antifungals and Urokinase Irrigation: A Case Report and Review of the Literature.
Pediatr Infect Dis J
January 2025
From the Department of Infection and Immunity.
Background: An ex-27-week gestation female infant developed bilateral forearm nodules at 4 weeks of life during treatment for methicillin-sensitive Staphylococcus aureus bacteremia. A pure growth of Candida albicans was isolated on culture of both sterile aspiration of the forearm abscess and urine without evidence of methicillin-sensitive Staphylococcus aureus . The patient went on to develop bilateral obstructive renal fungal bezoars at 11 weeks of life.
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