Background: Odontogenic tumors (OTs) are rare lesions, exclusive of the jaws, that are derived from epithelial and/or ectomesenchymal elements of the tooth-forming apparatus. Their biological behavior is heterogeneous, including hamartomatous tissue proliferation, benign nonaggressive and aggressive neoplasms, and malignant tumors with metastatic capacity. The aim of this study was to describe the relative frequency of odontogenic tumors in a Brazilian population. In addition, a review of the literature identified studies on odontogenic tumors that follow the 2005 World Health Organization.
Material And Methods: A total of 376 cases of odontogenic tumors from an oral pathology service were reviewed about age, gender, anatomic site and histologic diagnosis.
Results: Keratocystic odontogenic tumors (31.6%) were the most common, followed by ameloblastoma (28.5%), and odontoma (22.6%). The mean age was 32.2 years, and more than half the patients (52.1%) were in the second and third decades of life. The male to female ratio was 1:1.37, with a maxilla to mandible ratio of 1:2.08.
Conclusions: The variation in relative frequency of tumors observed among the several series, including the present study, is probably due in part to cultural differences between geographic areas but also to the study design.
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http://dx.doi.org/10.4317/medoral.21285 | DOI Listing |
BMC Oral Health
January 2025
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Background: Calretinin is a 29 kilodalton (KDa) calcium-binding protein that is expressed in normal and tumoral tissues. The expression of calretinin has been shown in the dental epithelium during odontogenesis and in different odontogenic cysts and tumors such as ameloblastoma. Since the epithelium of calcifying odontogenic cyst (COC) is similar to ameloblastoma and in both lesions, an arrangement of loose cells similar to stellate reticulum is seen, we aimed to investigate the comparative expression of calretinin in COC and ameloblastoma.
View Article and Find Full Text PDFJ Dent Res
January 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Odontogenic keratocyst (OKC) and ameloblastoma (AM) are common jaw lesions with high bone-destructive potential and recurrence rates. Recent advancements in technology led to significant progress in understanding these conditions. Single-cell and spatial omics have improved insights into the tumor microenvironment and cellular heterogeneity in OKC and AM.
View Article and Find Full Text PDFJ Dent Sci
January 2025
Department of Oral and Maxillofacial Radiology, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Background/purpose: This study analyzed the clinical and imaging features of lingual mandibular bone depression (LMBD) in the anterior mandible, aiming to prevent misdiagnosis and unnecessary surgical procedures.
Materials And Methods: The patients who visited a university dental hospital for painless radiolucency in the anterior mandible from January 2010 to December 2022 were retrospectively reviewed. Twelve cases of LMBD in the anterior mandible that are confirmed by biopsy or long-term follow-up were identified.
BMJ Case Rep
January 2025
Department of Oral and Maxillofacial Surgery, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Pondicherry, India.
A calcifying epithelial odontogenic tumour (CEOT) is a rare benign odontogenic tumour of epithelial origin accounting for approximately 1% of all odontogenic tumours. The intraosseous form occurs more commonly in the posterior mandible whereas the extraosseous form is common in the anterior maxilla. CEOT is often asymptomatic and presents with a painless swelling of the mandible.
View Article and Find Full Text PDFSemin Diagn Pathol
January 2025
Dept of Oral & Maxillofacial Pathology and Oral Microbiology, King George's Medical University, Lucknow, India. Electronic address:
Ameloblastomas (AM) are locally aggressive tumors, with hemangiomatous ameloblastoma (HA) being a rare subtype characterized by vascular proliferation, predominantly in the stroma but occasionally within the epithelial component. We report a case of a 32-year-old male with recurrent mandibular swelling, histopathologically diagnosed as unicystic HA, showing vascularity in both stroma and odontogenic epithelial islands with GLUT1 positivity in the latter. A review of 31 cases revealed a male predilection, mandibular dominance (89.
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