AI Article Synopsis
- A multi-disciplinary international working group is addressing ethical concerns in neuromodulation research for neuro-psychiatric disorders by proposing a new study design approach.
- The proposed strategy involves an iterative process where insights from both responders and non-responders in trials are continuously used to improve future research efforts.
- This methodology aims to enhance outcomes, improve knowledge utilization, and promote scientific discovery while ensuring ethical stewardship in the research process.
Article Abstract
As part of the efforts of a multi-disciplinary, international working group focused on ethical issues in neuromodulation for neuro-psychiatric disorders, we propose a novel; strategy for study design which iteratively applies new knowledge to on-going and future trials. Under current practice, device studies may be closed or categorized as "failures" before knowledge embedded in them can be fully mined. We propose the use of an iterative process to gain knowledge from subjects who have responded to those who have not. This approach can help maximize outcomes in non-responders and inform the design of future studies. This more agile yet rigorous methodology leverages information at all stages of investigation and promotes both scientific discovery and; stewardship.
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| http://dx.doi.org/10.1016/j.brs.2016.12.012 | DOI Listing |
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