Particle characteristics e.g. size and polymorphism are known to significantly affect the Pickering ability of the solid particles by influencing their interaction at the oil and water (O/W) interface. In this study, nano-sized amorphous curcumin particles were fabricated using nanonization technology to use them as Pickering particles. After nanonization, native crystalline curcumin particles were converted into amorphous, nanosized particles of ∼220nm. Amorphous nature of the particle was evident from the decreased melting point from 177±1°C (native curcumin) to 146±3°C (nanonized curcumin) and enthalpy from 27±2J/g to 3.5±1J/g. Interfacial tension (IFT) studies have shown a decrease in IFT at the O/W interface from ∼27mN/m to ∼15mN/m in the presence of amorphous curcumin particles in water phase compared to crystalline curcumin particles. Curcumin stabilized O/W emulsion has an initial droplet size of ∼1.2μm and they were stable for 30days at 4°C.
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http://dx.doi.org/10.1016/j.foodchem.2016.12.082 | DOI Listing |
Langmuir
December 2024
Key Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China.
The development of innovative solid particles from renewable resources possessing high biocompatibility and exceptional emulsification capabilities is crucial for stabilizing Pickering emulsions and advancing carrier systems. In this study, a pea protein isolate (PPI)-cellulose conjugate particle was prepared by the Maillard reaction. Compared to the isoelectric point of pH 4.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
School of Public Health, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China. Electronic address:
Pea protein nano-micelles gained with partial hydrolysis by a proteolytic enzyme (Protamex) were employed as nanocarriers to encapsulate and stabilize liable and hydrophobic curcumin (CUR) with two various methods (pH-driven method (PDM) and ethanol-induced method (EIM)). Both CUR-loaded pea protein hydrolysates (PPHs) nano-micelles by PDM and EIM exhibited spherical shapes, and uniform particle size distributions. Highest CUR loading amount (3.
View Article and Find Full Text PDFInt J Nanomedicine
December 2024
School of Life Science and Medicine, Shandong University of Technology, Zibo, 255000, People's Republic of China.
Purpose: This study aimed to synthesize curcumin-modified selenium (Cur/Se) nanoparticles via a simple and green method for tumour treatment and explore their effects on the gut microbiota.
Methods: Curcumin was applied as a reducing and capping agent for the construction of Cur/Se nanoparticles with Tween 80 as a stabilizer. The drug release behaviour and DPPH and ABTS radical scavenging activities of the Cur/Se nanoparticles were detected.
Chemphyschem
December 2024
Indian Institute of Technology Jodhpur, Chemistry, NH65, Surpura bypass road, karwar, 342037, Jodhpur, INDIA.
To improve bioavailability, enhance the solubility and stability of the hydrophobic drug curcumin, nanoparticles such as carbon quantum dots (CQDs) are unique choices. In this study, we present a simple, cost-effective, and eco-friendly method for synthesizing nitrogen-doped carbon quantum dots (N-CQDs) and their application in the efficient delivery of hydrophobic drugs curcumin into live cancer cells. The N-CQDs produced in this study exhibit excellent water solubility, remarkable stability, and high biocompatibility.
View Article and Find Full Text PDFDaru
December 2024
Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, POB 11795, Egypt.
Background: Bile salts enriched nanovesicles (bilosomes) have been attention worthy in the past few years due to their distinctive effect on the enhancement of drug delivery through various physiological administration routes. Oral delivery of multifunctioning phytochemical curcumin has faced a lot of difficulties due to its scarce solubility and poor oral bioavailability.
Objective: The current investigation aimed to develop curcumin loaded bilosomes for improvement of oral curcumin bioavailability with maximum efficiency and safety.
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