We report continuous-wave beam conversion from 1.06 to 1.49 µm in a diamond Raman laser operating on the second Stokes shift. High power (114 W) and high conversion efficiency (44%) is achieved using a single cavity that is highly resonant at the first Stokes wavelength but has high output coupling at the second Stokes wavelength (89%). An analytical model was developed for external-cavity Raman lasers operating in steady-state, revealing that optimization of second Stokes output is markedly different to first Stokes and that there is a direct and proportional relationship between the second Stokes output coupling and the pump depletion in the diamond, which we have confirmed by experiment. This technology shows promise for power scaling beyond the capabilities of current fiber lasers operating in the applications-rich 1.5-1.6 µm wavelength range.
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http://dx.doi.org/10.1364/OE.25.000749 | DOI Listing |
Introduction: Systemic lupus erythematosus (SLE) causes widespread inflammation and damage in affected organs. Severity is determined by the type of organ systems affected and the extent of involvement. SLE occurs in childhood or adulthood and disease severity varies according to age of onset.
View Article and Find Full Text PDFOrg Biomol Chem
January 2025
Department of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China.
detection of hypochlorous acid (HOCl) is critical for understanding its complex physiological and pathological roles. Fluorescent probes, known for their sensitivity and selectivity, are the preferred approach for such detections. Anthracene carboxyimide, an analog of naphthalimide, offers extended excitation and emission wavelengths, making it an excellent candidate for developing new fluorescent probes that address the limitations of naphthalimide.
View Article and Find Full Text PDFAnn Thorac Surg Short Rep
September 2024
Department of Thoracic & Cardiovascular Surgery, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio.
We present the case of a 41-year-old man with an anterior mediastinal mass and constellation of clinical symptoms, including dyspnea, pleural effusions, pericardial effusions, renal insufficiency, and pancytopenia. After inconclusive results on several laboratory tests and a nondiagnostic surgical biopsy specimen, a specimen from a second surgical biopsy identified the patient's condition as Castleman disease associated with TAFRO (thrombocytopenia, anasarca, fevers, reticulin myelofibrosis, organomegaly) syndrome. This case highlights the importance of obtaining large tissue biopsy samples, interval follow-up, and acknowledging cognitive biases.
View Article and Find Full Text PDFVet Ophthalmol
January 2025
Cardiology & Cardiac Surgery, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
A 4-year-old female spayed mixed-breed dog received enucleation surgery of the right eye in 2018 following the diagnosis of glaucoma. The patient was presented in 2021 for recurrent swelling of the right orbit. Ultrasound confirmed the presence of a cystic structure, and chemical ablation with 1% polidocanol (compounded, Stokes Pharmacy, Mt.
View Article and Find Full Text PDFMolecules
December 2024
Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia.
As the resistance of to the existing antimalarials increases, there is a crucial need to expand the antimalarial drug pipeline. We recently identified potent antimalarial compounds, namely harmiquins, hybrids derived from the β-carboline alkaloid harmine and 4-amino-7-chloroquinoline, a key structural motif of chloroquine (CQ). To further explore the structure-activity relationship, we synthesised 13 novel hybrid compounds at the position -9 of the β-carboline ring and evaluated their efficacy in vitro against 3D7 and Dd2 strains (CQ sensitive and multi-drug resistant, respectively).
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