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Linagliptin Mitigates DMH-Induced Colorectal Cancer in Rats: Crosstalk Between NFAT and IL-6/JAK2/STAT3/NF-κB Signaling Hubs.
J Biochem Mol Toxicol
March 2025
Biochemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Colorectal cancer (CRC) is a multicomponent disease and the second most frequent root of cancer-related deaths globally. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It has been repurposed in recent experimental studies due to its marked anti-inflammatory activities.
View Article and Find Full Text PDFEffects of Exercise on Depression and Anxiety in Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Cancer Med
March 2025
Beijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University, Beijing, China.
Background: Numerous studies have investigated the effects of exercise on depression and anxiety in breast cancer survivors, yet the results remain inconsistent. The aim of this study was to investigate the effects of exercise on depression and anxiety in breast cancer survivors and to ascertain the optimal exercise regimen for this patient population.
Methods: A comprehensive search was conducted across Embase, PubMed, the Cochrane Library, Web of Science, and Scopus until 28 October 2023.
Pharmacokinetics and bioequivalence of two formulations of the S-1 (tegafur/gimeracil/oxonate) capsule in Chinese cancer patients under fasting and fed conditions: a multicenter, randomized, open-label, single-dose, double-cycle crossover study.
Front Pharmacol
February 2025
Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha, Hunan, China.
Objective: S-1, an oral multicomponent capsule containing tegafur, gimeracil, and potassium oxonate, has demonstrated efficacy in various tumor types. This study aimed to assess the pharmacokinetics, bioequivalence (BE), and safety of a newly developed generic S-1 capsule compared to the original brand-name formulation in Chinese cancer patients under fasting and fed conditions.
Methods: A multicenter, randomized, open-label, single-dose, double-cycle crossover study was conducted in Chinese cancer patients.
A Multicomponent Behavior Change and Implementation Strategy to Increase Lung Cancer Screening in Primary Care Practices: The IBREATHE Study.
J Am Coll Radiol
March 2025
Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York; Associate Director of Community Outreach and Engagement, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York.
Objectives: Despite broader eligibility under the 2021 US Preventive Services Task Force guidelines, national lung cancer screening (LCS) uptake remains at around 16%. This radiologist-led study sought to identify LCS barriers in primary care settings and develop a theory-based behavior change and implementation strategy to improve screening rates in these settings.
Methods: A multiphase approach was used, including qualitative methods and frameworks (ie, Behavior Change Wheel; Capability, Opportunity, and Motivation of Behavior model; Theoretical Domains Framework; and Expert Recommendations for Implementing Change glossary) to understand and address LCS barriers.
Complementing therapeutic strategies for acute myeloid leukemia: Signaling pathways and targets of traditional Chinese medicine.
Leuk Res
February 2025
Department of Pediatric Medicine, The First People's Hospital of Jiashan, China. Electronic address:
Leukemia is a heterogeneous malignant tumor of the hematopoietic system and is characterized by the blockage of differentiation and uncontrolled proliferation of myeloid or lymphoid progenitor cells in the bone marrow and peripheral blood. Currently, intensified chemotherapy regimens and hematopoietic stem cell transplantation (HSCT) are the most common treatment methods for various types of leukemia. However, they are associated with severe side effects and multidrug resistance.
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