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MK-801 attenuates one-trial tolerance in the elevated plus maze via the thalamic nucleus reuniens.
Neuropharmacology
January 2025
Nanhu Brain-computer Interface Institute, Hangzhou 311100, China; Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058 Hangzhou, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, 1369 West Wenyi Road, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China. Electronic address:
Anxiety, a future-oriented negative emotional state, is characterized by heightened arousal and vigilance. The elevated plus maze (EPM) test is a widely used assay of anxiety-related behaviors in rodents and shows a phenomenon where animals with prior test experience tend to avoid open arms in retest sessions. While this one-trial tolerance (OTT) phenomenon limits the reuse of the EPM test, the potential mechanisms remain unsolved.
View Article and Find Full Text PDFThe influences of social support expressed from doctors and disclosed from peers on patient decision-making: an analysis from the online health community.
Sci Rep
January 2025
School of Management, Hainan Medical University, Haikou, China.
Patients are turning to OHCs to deal with the stresses and complications of infertility. As a stigmatized disease, infertile patients may value informational support and emotional support differently, which is ignored in existing studies. Based on social support theory, this study aims to reveal the role of informational support and emotional support of doctors in infertile patient decision-making.
View Article and Find Full Text PDFClinical Interplay Between Autism Spectrum Disorder and Bipolar Disorder: A Narrative Review.
Trends Psychiatry Psychother
January 2025
Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. Graduate Program in Psychiatry and Behavioral Sciences, Department of Psychiatry and Legal Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. National Institute of Science and Technology for Translational Medicine (INCT-TM), Porto Alegre, RS, Brazil. Faculty of Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
Introduction: Autism Spectrum Disorder (ASD) and Bipolar Disorder (BD) present significant challenges in diagnosis due to their complex nature. This review aims to examine the interface and overlapping features of these conditions.
Methods: We conducted a narrative review to examine clinical overlap, common psychiatric comorbidities, and shared neurobiological bases between ASD and BD.
The current clinical approach to feeding and eating disorders aimed to increase personalization of management.
World Psychiatry
February 2025
School of Health in Social Science, University of Edinburgh, Edinburgh, UK.
Feeding and eating disorders (FEDs) are a heterogeneous grouping of disorders at the mind-body interface, with typical onset from childhood into emerging adulthood. They occur along a spectrum of disordered eating and compensatory weight management behaviors, and from low to high body weight. Psychiatric comorbidities are the norm.
View Article and Find Full Text PDF[Employing Emotional Virtual Characters for Teaching in Child and Adolescent Psychiatry].
Z Kinder Jugendpsychiatr Psychother
January 2025
Lehrstuhl für Medieninformatik | Entertainment Computing Group, Universität Duisburg-Essen, Deutschland.
Employing Emotional Virtual Characters for Teaching in Child and Adolescent Psychiatry Communication and interaction are central to teaching child and adolescent psychiatry, with practical exercises often needing more access to actual patients or actors. Virtual reality (VR) offers an innovative solution by enabling simulation-based learning. With the help of computer-generated, interactive characters, students can practice repeatedly and in a standardized way how to conduct a medical interview and acquire communication skills.
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