Environmental microbes like has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in challenged to combat against the infection. Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of DSM 12804 (accession No. PRJNA28135) from genome database of National Centre for Biotechnology information. In this regards, the inhibitory effect of nine natural compounds like ajoene (), allicin (), cinnamaldehyde (), curcumin (), gallotannin (active component of green tea and red wine), isoorientin (), isovitexin (), neral (), and vitexin () have been acknowledged with anti-bacterial properties and hence tested against identified drug target of by implicating computational approach. The studies revealed the hypothesis that lpxD could be a potential drug target and with recommendation of a strong inhibitory effect of selected natural compounds against infection caused due to , would be further validated through experiments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287131 | PMC |
| http://dx.doi.org/10.5808/GI.2016.14.4.241 | DOI Listing |
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