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Spinal cord diffusion-tensor imaging and motor-evoked potentials in multiple sclerosis patients: microstructural and functional asymmetry.
Radiology
June 2013
Department of Neuroradiology, University Hospital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland.
Purpose: To assess possible association between intrinsic structural damage and clinical disability by correlating spinal cord diffusion-tensor (DT) imaging data with electrophysiological parameters in patients with a diagnosis of multiple sclerosis (MS).
Materials And Methods: This study was approved by the local ethical committee according to the declaration of Helsinki and written informed consent was obtained. DT images and T1- and T2-weighted images of the spinal cord were acquired in 28 healthy volunteers and 41 MS patients.
Grey matter changes associated with medication-overuse headache: correlations with disease related disability and anxiety.
World J Biol Psychiatry
October 2012
Department of Neurology, Headache Unit, University Hospital Zurich, Zurich, Switzerland.
Objectives: Medication-overuse headache (MOH) is associated with psychiatric comorbidities. Neurobiological similarities to substance dependence have been suggested. This study investigated grey matter changes, focussing on pain and reward systems.
View Article and Find Full Text PDFChronic cervical spinal cord injury: DTI correlates with clinical and electrophysiological measures.
J Neurotrauma
May 2012
Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
Diffusion tensor imaging (DTI) is rarely applied in spinal cord injury (SCI). The aim of this study was to correlate diffusion properties after SCI with electrophysiological and neurological measures. Nineteen traumatic cervical SCI subjects and 28 age-matched healthy subjects participated in this study.
View Article and Find Full Text PDFAcute coronary syndromes in young patients: presentation, treatment and outcome.
Int J Cardiol
May 2011
Department of Geriatrics and General Internal Medicine, University of Berne Hospital Inselspital, Institute of Social and Preventive Medicine, University of Berne, Berne, Switzerland.
Background: Acute coronary syndromes (ACS) in very young patients have been poorly described. We therefore evaluate ACS in patients aged 35 years and younger.
Methods: In this prospective cohort study, 76 hospitals treating ACS in Switzerland enrolled 28,778 patients with ACS between January 1, 1997, and October 1, 2008.
Is pretreatment with Beta-blockers beneficial in patients with acute coronary syndrome?
Cardiology
March 2010
Department of Cardiology, University Hospital Bern, Bern, Switzerland.
Objectives: The role of beta-blockers in the treatment of hypertension is discussed controversially and the data showing a clear benefit in acute coronary syndromes (ACS) were obtained in the thrombolysis era. The goal of this study was to analyze the role of pretreatment with beta-blockers in patients with ACS.
Methods: Using data from the Acute Myocardial Infarction in Switzerland (AMIS Plus) registry, we analyzed outcomes of patients with beta-blocker pretreatment in whom they were continued during hospitalization (group A), those without beta-blocker pretreatment but with administration after admission (group B) and those who never received them (group C).
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