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Adapted evolution towards flagellar loss in Pseudomonas syringae.
Microbiol Res
January 2025
Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China. Electronic address:
The flagellum is a complex molecular nanomachine crucial for cell motility. Its assembly requires coordinated expression of over 50 flagellar genes, regulated by the transcription activator FleQ. Phylogenomic analyses suggest that many non-flagellated bacterial species have evolved from flagellated ancestors by losing specific flagellar components, though the evolutionary mechanisms driving this process remain unclear.
View Article and Find Full Text PDFMRI Detection of Lymph Node Metastasis through Molecular Targeting of C-C Chemokine Receptor Type 2 and Monocyte Hitchhiking.
ACS Nano
January 2024
Department of Biomedical Engineering, University of Southern California, Los Angeles, California 90089, United States.
Biopsy is the clinical standard for diagnosing lymph node (LN) metastasis, but it is invasive and poses significant risk to patient health. Magnetic resonance imaging (MRI) has been utilized as a noninvasive alternative but is limited by low sensitivity, with only ∼35% of LN metastases detected, as clinical contrast agents cannot discriminate between healthy and metastatic LNs due to nonspecific accumulation. Nanoparticles targeted to the C-C chemokine receptor 2 (CCR2), a biomarker highly expressed in metastatic LNs, have the potential to guide the delivery of contrast agents, improving the sensitivity of MRI.
View Article and Find Full Text PDFProbing neurodynamics of experienced emotions-a Hitchhiker's guide to film fMRI.
Soc Cogn Affect Neurosci
November 2023
Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva 1202, Switzerland.
Film functional magnetic resonance imaging (fMRI) has gained tremendous popularity in many areas of neuroscience. However, affective neuroscience remains somewhat behind in embracing this approach, even though films lend themselves to study how brain function gives rise to complex, dynamic and multivariate emotions. Here, we discuss the unique capabilities of film fMRI for emotion research, while providing a general guide of conducting such research.
View Article and Find Full Text PDFDevelopment of ionic liquid-coated PLGA nanoparticles for applications in intravenous drug delivery.
Nat Protoc
August 2023
Department of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, USA.
Polymeric nanoparticles (NPs) are a promising platform for medical applications in drug delivery. However, their use as drug carriers is limited by biological (e.g.
View Article and Find Full Text PDFProgrammed antigen capture-harnessed dendritic cells by margination-hitchhiking lung delivery.
J Control Release
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Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan. Electronic address:
Adoptive T cells and immunotherapy suppress the most destructive metastatic tumors and prevent tumor recurrence by inducing T lymphocytes. However, the heterogeneity and immune privilege of invasive metastatic clusters often reduce immune cell infiltration and therapeutic efficacy. Here, the red blood cells (RBC)-hitchhiking mediated lung metastasis delivery of multi-grained iron oxide nanostructures (MIO) programming the antigen capture, dendritic cell harnessing, and T cell recruitment is developed.
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