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Towards affordable biomedical imaging: Recent advances in low-cost, high-resolution optoacoustic microscopy.
J Microsc
December 2024
Department of Biology, University of Crete, Voutes University Campus, Heraklion, Crete, Greece.
This short review discusses the recent developments in low-cost, high-resolution optoacoustic microscopy systems, integrating laser diodes for signal excitation, which are 20-40 times cheaper than the typically employed Q-switched nanosecond laser sources. The development of laser diode-based microscopes can substantially improve not only cost efficiency, but also multispectral capabilities, robustness, portability and overall imaging performance of the optoacoustic technique. To this end, we demonstrate relevant implementations in both time and frequency domain, highlighting their representative applications in biomedical research such as microvasculature imaging, oxygen saturation assessments, hybrid and multiview microscopy of model organisms and tissues and Doppler flow speed measurements.
View Article and Find Full Text PDFMultispectral imaging in medicine: A bibliometric study.
Heliyon
August 2024
Department of Dermatology, Xiangya Hospital, Central South University, Hunan, 410008, China.
Article Synopsis
- Multispectral Imaging is gaining traction in various fields, particularly in medicine, where its potential is just starting to be explored.
- This paper conducts the first bibliometric analysis of this emerging field, reviewing documents from 1999 to 2022 to identify key authors, journals, countries, and trends.
- The study highlights the need for collaboration among researchers and healthcare professionals to enhance the application of Multispectral Imaging in medicine, with a focus on integrating AI and improving non-ex vivo tissue detection in future developments.
Non-invasive optoacoustic imaging of glycogen-storage and muscle degeneration in late-onset Pompe disease.
Nat Commun
September 2024
Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, 91054, Germany.
Pompe disease (PD) is a rare autosomal recessive glycogen storage disorder that causes proximal muscle weakness and loss of respiratory function. While enzyme replacement therapy (ERT) is the only effective treatment, biomarkers for disease monitoring are scarce. Following ex vivo biomarker validation in phantom studies, we apply multispectral optoacoustic tomography (MSOT), a laser- and ultrasound-based non-invasive imaging approach, in a clinical trial (NCT05083806) to image the biceps muscles of 10 late-onset PD (LOPD) patients and 10 matched healthy controls.
View Article and Find Full Text PDFArticle Synopsis
- Tumor hypoxia in pediatric malignant rhabdoid tumors (MRT) leads to resistance against radiation therapy, worsening treatment outcomes.
- Researchers repurposed an FDA-approved drug, Atovaquone (AVO), to reduce oxygen consumption in tumors, enhancing their sensitivity to low-dose radiation therapy.
- Using multispectral optoacoustic tomography (MSOT), they monitored oxygen levels in tumors, finding that AVO increased oxygen saturation before radiation treatment, which correlated with improved anti-tumor responses, while resistance to AVO diminished its effectiveness.
Non-invasive optoacoustic imaging of dermal microcirculatory revascularization in diet-induced obese mice undergoing exercise intervention.
Photoacoustics
August 2024
Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Microcirculatory dysfunction has been observed in the dermal white adipose tissue (dWAT) and subcutaneous white adipose tissue (scWAT) of obese humans and has been proposed as an early prediction marker for cardio-metabolic disease progression. visualization and longitudinal monitoring of microvascular remodeling in these tissues remains challenging. We compare the performance of two optoacoustic imaging methods, i.
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