AI Article Synopsis
- Curcumin is a natural compound known for its biological and pharmaceutical benefits, particularly against infections, and this study compared five different curcumin samples to assess their effectiveness.
- The research involved a mouse model to measure various biological markers and responses, including lipid peroxide levels, bacterial colonization, and the immune response.
- Among the samples tested, the Sabinsa sample stood out as the most effective, as others showed varying levels of activity but none consistently matched its effectiveness.
Article Abstract
Background: Curcumin is a well-established natural molecule with significant biological and pharmaceutical effects. Its effects on () infection have been repeatedly confirmed both in animal and human models. This study directly compared five different samples to evaluate if the effects are general or if they differ among samples.
Methods: Using a mouse model, we studied the effects of curcumin on lipid peroxide (LPO) level, myeloperoxidase (MPO) and urease activity, number of colonized bacteria, levels of anti- antibodies, biofilm formation, IFN-γ, IL-4, gastrin and somatostatin levels in serum, and minimum inhibitory concentration. In addition, we evaluated the effects on biofilm production and antibacterial antibody response.
Results: In all tests, one sample (Sabinsa) was consistently the most active.
Conclusions: All curcumin samples showed some anti- effects, but only some of the tested samples had significant activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233496 | PMC |
| http://dx.doi.org/10.21037/atm.2016.12.52 | DOI Listing |
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