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Forming Connections: Functional Brain Connectivity is Associated With Executive Functioning Abilities in Early Childhood.
Dev Sci
March 2025
Division of Developmental Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
Functional magnetic resonance imaging (fMRI) studies with adults provide evidence that functional brain networks, including the default mode network and frontoparietal network, underlie executive functioning (EF). However, given the challenges of using fMRI with infants and young children, little work has assessed the developmental trajectories of these networks or their associations with EF at key developmental stages. More recently, functional near-infrared spectroscopy (fNIRS) has emerged as a promising neuroimaging tool which can provide information on cortical functional networks and can be more easily implemented with young children.
View Article and Find Full Text PDFAntibodies to watch in 2025.
MAbs
December 2025
Business Intelligence Research, The Antibody Society, Inc., Framingham, MA, USA.
The commercial development of antibody therapeutics is a global enterprise involving thousands of biopharmaceutical firms and supporting service organizations. To date, their combined efforts have resulted in over 200 marketed antibody therapeutics and a pipeline of nearly 1,400 investigational product candidates that are undergoing evaluation in clinical studies as treatments for a wide variety of diseases. Here, we discuss key events in antibody therapeutics development that occurred during 2024 and forecast key events related to the late-stage clinical pipeline that may occur in 2025.
View Article and Find Full Text PDFProvider assisted partner notification utilization and associated factors among adolescents living with HIV in Uganda, a cross-sectional study.
BMC Pediatr
November 2024
Department of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Background: Assisted Partner Notification (APN) is a high yield HIV testing strategy that is recommended by the World Health Organization (WHO) for adults and adolescents aged at least 15 years in sub-Saharan Africa for HIV care and prevention. Although studies among adults have been done, there remains a paucity of data of APN service utilization among adolescents in Uganda, yet Adolescents Girls and Young Women (AGYW) have the highest incidence of HIV in Uganda, and generally, adolescents have the lowest HIV viral suppression rates. Failure to disclose to sexual partners poses a risk of propagating infection.
View Article and Find Full Text PDFEnvironmental Antimicrobial Resistance: Implications for Food Safety and Public Health.
Antibiotics (Basel)
November 2024
School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK.
Antimicrobial resistance (AMR) is a serious global health issue, aggravated by antibiotic overuse and misuse in human medicine, animal care, and agriculture. This study looks at the different mechanisms that drive AMR, such as environmental contamination, horizontal gene transfer, and selective pressure, as well as the severe implications of AMR for human and animal health. This study demonstrates the need for concerted efforts across the scientific, healthcare, agricultural, and policy sectors to control the emergence of AMR.
View Article and Find Full Text PDFAssessing antimicrobial consumption in public and private sectors within the Costa Rican health system: current status and future directions.
BMC Public Health
November 2024
CUFAR-University Centre of Pharmacology, UNLP, WHO-PAHO Col, La Plata, 1900, Argentina.
Background: Antimicrobial resistance is a significant global health threat. Therefore, robust surveillance systems for antimicrobial consumption (AMC) are essential to develop public health strategies. However, Latin American countries, including Costa Rica, face challenges in regularly reporting AMC data.
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