[This corrects the article DOI: 10.1371/journal.pbio.1001856.].
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http://dx.doi.org/10.1371/journal.pbio.1002595 | DOI Listing |
Nat Commun
October 2021
Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.
The chromatin remodeler RSF1 enriched at mitotic centromeres is essential for proper chromosome alignment and segregation and underlying mechanisms remain to be disclosed. We here show that PLK1 recruitment by RSF1 at centromeres creates an activating phosphorylation on Thr236 in the activation loop of Aurora B and this is indispensable for the Aurora B activation. In structural modeling the phosphorylated Thr236 enhances the base catalysis by Asp200 nearby, facilitating the Thr232 autophosphorylation.
View Article and Find Full Text PDFPLoS One
March 2014
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
Yeast sporulation efficiency is a quantitative trait and is known to vary among experimental populations and natural isolates. Some studies have uncovered the genetic basis of this variation and have identified the role of sporulation genes (IME1, RME1) and sporulation-associated genes (FKH2, PMS1, RAS2, RSF1, SWS2), as well as non-sporulation pathway genes (MKT1, TAO3) in maintaining this variation. However, these studies have been done mostly in experimental populations.
View Article and Find Full Text PDFPLoS One
August 2013
Department of Biology and Environmental Science, Heidelberg University, Tiffin, Ohio, United States of America.
Age at menarche (AM) and age at natural menopause (ANM) define the boundaries of the reproductive lifespan in women. Their timing is associated with various diseases, including cancer and cardiovascular disease. Genome-wide association studies have identified several genetic variants associated with either AM or ANM in populations of largely European or Asian descent women.
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