Objective: Due to the sparse data on benzene exposure and myelodysplastic syndrome (MDS) subtypes, we studied this relationship in patients from 29 hospitals in Shanghai, China.
Methods: We recruited 604 cases of MDS and 1193 controls matched on age, sex, and admission date. We interviewed subjects for information on workplace and lifestyle exposures, and developed semi-quantitative exposure estimates.
Results: Benzene exposure showed a direct exposure-response pattern with refractory cytopenia with multilineage dysplasia, a less certain association with refractory cytopenia with unilineage dysplasia, and no association with other MDS subtypes. A different pattern was observed with farm residence and smoking, which was primarily related to refractory anemias.
Conclusions: This research demonstrates the importance of MDS subtype specification for more robust etiologic insights. Our data suggests that subtypes with non-erythroid dysplasia are associated with benzene exposure.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374749 | PMC |
| http://dx.doi.org/10.1097/JOM.0000000000000952 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Active phytoextraction of toluene shifts the microbiome and enhances degradation capacity in hybrid poplar.
J Environ Manage
December 2024
School of Environmental Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON, N1H 2W1, Canada. Electronic address:
Hybrid poplars are widely recognized for their effectiveness in remediating subsurface aromatic hydrocarbon contaminants, including benzene, toluene, ethylbenzene, and xylene isomers (BTEX). While BTEX compounds are frequently found in the transpiration streams of poplars at contaminated sites, the microbial dynamics within these trees, particularly in response to hydrocarbon exposure, remain underexplored. This study utilized high-throughput amplicon sequencing to investigate the trunk microbiome in hybrid poplars at a field-scale toluene phytoremediation site.
View Article and Find Full Text PDFInvestigating the effects of co-exposure to noise and benzene on serum oxidative stress in rat.
Toxicol Rep
December 2024
Department of Occupational Health and Ergonomic, Qazvin Medical University, Qazvin, Iran.
Occupational exposures are generally complex, workers are exposed with more than one hazardous agent in work environment. Combined exposure to noise and benzene is common in occupational environments. Sub-acute exposure to benzene vapors can induce oxidative stress in serum.
View Article and Find Full Text PDFVolatile hydrocarbon exposures and immune-related illnesses among Deepwater Horizon oil spill workers.
J Expo Sci Environ Epidemiol
December 2024
Department of Epidemiology, UNC Gillings School of Public Health, Chapel Hill, NC, USA.
Background: Despite evidence from experimental studies linking some petroleum hydrocarbons to markers of immune suppression, limited epidemiologic research exists on this topic.
Objective: The aim of this cross-sectional study was to examine associations of oil spill related chemicals (benzene, toluene, ethylbenzene, xylene, and n-hexane (BTEX-H)) and total hydrocarbons (THC) with immune-related illnesses as indicators of potential immune suppression.
Methods: Subjects comprised 8601 Deepwater Horizon (DWH) oil spill clean-up and response workers who participated in a home visit (1-3 years after the DWH spill) in the Gulf Long-term Follow-up (GuLF) Study.
Diethyl nitrosamine-induces neurobehavioral deficit, oxido-nitrosative stress in rats' brain: a neuroprotective role of diphenyl diselenide.
BMC Neurosci
December 2024
Department of Anatomy, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo State, Nigeria.
Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced neurotoxicity in male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts and treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) and DEN-only (200 mg/kg; single dose i.
View Article and Find Full Text PDFEffects of dichlorobenzene, toluene, benzene and formaldehyde chemicals on Drosophila melanogaster mortality.
Environ Geochem Health
December 2024
School of Mechanical Engineering, Tongji University, Shanghai, 200092, China.
Environmental exposures to volatile organic compound (VOC) mixtures have received increasing attention, yet the risks are under studied. This study aimed to explore the risks of combined exposures to several commonly detected VOCs and to draw attention to the necessity of studying long-term and low-concentration environmental exposure patterns. In this study, we examined the effects of long-term and low-concentration exposures to VOCs like 1,2-dichlorobenzene, benzene, toluene and formaldehyde either alone or in combination on D.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!