We describe a VLBI experiment in which, for the first time, the clock reference is delivered from a National Metrology Institute to a radio telescope using a coherent fibre link 550 km long. The experiment consisted of a 24-hours long geodetic campaign, performed by a network of European telescopes; in one of those (Medicina, Italy) the local clock was alternated with a signal generated from an optical comb slaved to a fibre-disseminated optical signal. The quality of the results obtained with this facility and with the local clock is similar: interferometric fringes were detected throughout the whole 24-hours period and it was possible to obtain a solution whose residuals are comparable to those obtained with the local clock. These results encourage further investigation of the ultimate VLBI performances achievable using fibre dissemination at the highest precision of state-of-the-art atomic clocks.
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http://dx.doi.org/10.1038/srep40992 | DOI Listing |
Unlabelled: Circadian rhythms in mammals arise from the spatiotemporal synchronization of ∼20,000 neuronal clocks in the Suprachiasmatic Nucleus (SCN). While anatomical, molecular, and genetic approaches have revealed diverse cell types and signaling mechanisms, the network wiring that enables SCN cells to communicate and synchronize remains unclear. To overcome the challenges of revealing functional connectivity from fixed tissue, we developed MITE (Mutual Information & Transfer Entropy), an information theory approach that infers directed cell-cell connections with high fidelity.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Clinical Biochemistry, Bispebjerg University Hospital, 2400 Copenhagen, Denmark.
Many endocrine glands exhibit circadian rhythmicity, but the interplay between the central circadian clock in the suprachiasmatic nucleus (SCN), the peripheral endocrine clock, and hormones is sparsely understood. We therefore studied the cellular localizations of the clock protein PER1, parathyroid hormone (PTH) and calcitonin (CT) in the parathyroid and thyroid glands, respectively. Thyroid glands, including the parathyroids, were dissected at different time-points from rats housed in 12 h:12 h light-darkness cycles, and were double-immunostained for PER1 and PTH or CT.
View Article and Find Full Text PDFEur J Neurosci
January 2025
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
The adaptation to the daily 24-h light-dark cycle is ubiquitous across animal species and is crucial for maintaining fitness. This free-running cycle occurs innately within multiple bodily systems, such as endogenous circadian rhythms in clock-gene expression and synaptic plasticity. These phenomena are well studied; however, it is unknown if and how the 24-h clock affects electrophysiologic network function in vivo.
View Article and Find Full Text PDFJ Palliat Med
December 2024
Northeast Ohio Medical University, Rootstown, Ohio, USA.
This report highlights the development of Grace House Akron, Inc. (GHA) a comfort care home focused on caring for terminally ill individuals who are unhoused, isolated, without caregivers, economically disadvantaged and face end of life alone. GHA is a free-standing home that provides safe housing, a nurturing environment, and round-the-clock personal care while local hospice agencies provide medical management.
View Article and Find Full Text PDFJ Acoust Soc Am
December 2024
Cooperative Institute for Marine Ecosystem and Resources Studies and Marine Mammal Institute, Oregon State University and National Oceanic and Atmospheric Administration Pacific Marine Environmental Laboratory, Newport, Oregon 97365, USA.
Confidence intervals of location of calling marine mammals, derived from time differences of arrival (TDOA) between receivers, depend on errors of TDOAs, receiver location, clocks, sound speeds, and location method. Simulations demonstrate Ishmael, a TDOA locator based on uncorrected least squares minimization (ULSM), yields errors with mean, standard deviation, and maximum of 0.1, 0.
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