AI Article Synopsis
- Duraplasty is a common procedure in about 30% of neurological surgeries, and various materials are tested for effectiveness in dura mater repair.
- Researchers evaluated bacterial cellulose (BC) membranes made from sugarcane molasses for repairing dural defects in an experiment with Wistar rats, comparing them to a control group using ePTFE.
- After 120 days of observation, BC membranes demonstrated good biocompatibility with no adverse effects like infections or inflammation, indicating they might be a safe option for dura mater repair.
Article Abstract
Duraplasty is necessary in nearly 30% of all neurological surgeries. Different tissues and materials have been evaluated in dura mater repair or as dural substitutes in neurosurgery. The aim was to evaluate the biocompatibility of the bacterial cellulose (BC) membranes, produced from sugarcane molasses, for dural defect repair in rats. Forty adults males Wistar rats divided into two groups: a control (ePTFE) and an experimental (BC). Bilateral frontoparietal craniectomy was performed, and a dural defect was created. The arachnoid underlying defect was disrupted with a narrow hook. The animals were observed for 120 days. There were no cases of infection, cerebrospinal fluid fistulae, delayed hemorrhages, behavior disturbances, seizures and palsies. The BC membrane showed to have suitable biocompatibility properties, was not induced immune reaction, nor chronic inflammatory response and absence of neurotoxicity signals.
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| http://dx.doi.org/10.1007/s10856-016-5828-9 | DOI Listing |
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