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Virus-Based Neural Circuit Tracing.
Adv Neurobiol
November 2024
The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, China.
Neural circuits provide an anatomical basis for functional networks. Therefore, dissecting the structure of neural circuits is an indispensable prerequisite to understanding how the brain functions. Knowing how the neural circuits organize and function under physiological conditions and their progressive alterations under pathophysiological conditions are key to understanding the underlying circuit mechanism of diseases, thus finding cures for the diseases.
View Article and Find Full Text PDFMounting evidence implicates trans-synaptic connectome-based spread as a shared mechanism behind different tauopathic conditions, yet also suggests there is divergent spatiotemporal progression between them. A potential parsimonious explanation for this apparent contradiction could be that different conditions incur differential rates and directional biases in tau transmission along fiber tracts. In this meta-analysis we closely examined this hypothesis and quantitatively tested it using spatiotemporal tau pathology patterns from 11 distinct models across 4 experimental studies.
View Article and Find Full Text PDFThe role of spinal neurons targeted by corticospinal neurons in central poststroke neuropathic pain.
CNS Neurosci Ther
June 2024
Department of Neurosurgery and Neurocritical Care, Huashan Hospital, Fudan University, Shanghai, China.
Background: Central poststroke pain (CPSP) is one of the primary sequelae following stroke, yet its underlying mechanisms are poorly understood.
Methods: By lesioning the lateral thalamic nuclei, we first established a CPSP model that exhibits mechanical and thermal hypersensitivity. Innocuous mechanical stimuli following the thalamic lesion evoked robust neural activation in somatosensory corticospinal neurons (CSNs), as well as in the deep dorsal horn, where low threshold mechanosensory afferents terminate.
Anterograde trans-neuronal labeling of striatal interneurons in relation to dopamine neurons in the substantia nigra pars compacta.
Front Neuroanat
February 2024
Laboratory of Cytology and Histology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Recent advances in neural tracing have unveiled numerous neural circuits characterized by brain region and cell type specificity, illuminating the underpinnings of specific functions and behaviors. Dopaminergic (DA) neurons in the midbrain are highly heterogeneous in terms of gene and protein expression and axonal projections. Different cell types within the substantia nigra pars compacta (SNc) tend to project to the striatum in a cell-type-dependent manner characterized by specific topography.
View Article and Find Full Text PDFTrans-Synaptic Degeneration in the Visual Pathway in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Neurology
April 2024
From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
Background And Objectives: We aimed to assess the presence of retinal neurodegeneration independent of optic neuritis (ON) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to investigate the development of trans-synaptic anterograde degeneration in these patients after ON.
Methods: Cross-sectional, retrospective study of 34 adult patients with MOGAD and 23 healthy controls (HC). Clinical, optical coherence tomography (OCT), and MRI data were collected.
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