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Atomic force microscopy for characterization of decellularized extracellular matrix (dECM) based materials.
Sci Technol Adv Mater
October 2024
Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
In live organisms, cells are embedded in tissue-specific extracellular matrix (ECM), which provides chemical and mechanical signals important for cell differentiation, migration, and overall functionality. Careful reproduction of ECM properties in artificial cell scaffolds is necessary to get physiologically relevant results of in vitro studies and produce robust materials for cell and tissue engineering. Nanoarchitectonics is a contemporary way to building complex materials from nano-scale objects of artificial and biological origin.
View Article and Find Full Text PDFResveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites.
Mech Ageing Dev
June 2024
Centre for Stress and Age-related Disease, Centre for Regenerative Medicine and Devices, Huxley Building, University of Brighton, Lewes Road, Brighton, East Sussex BN2 4GJ. Electronic address:
Progressive liver disease and dysfunction cause toxic metabolites including ammonia and unconjugated bilirubin to accumulate in plasma. As the population ages alternatives to liver transplantation become increasingly important. One approach for use as a bridge to transplant or recovery is the use of bioartificial liver systems (BALS) containing primary or immortalised hepatocytes as ex-vivo replacements or supports for endogenous liver function.
View Article and Find Full Text PDFA bioartificial and vasculomorphic bone matrix-based organoid mimicking microanatomy of flat and short bones.
J Biomed Mater Res B Appl Biomater
January 2024
ISSMC, CNR, Faenza, Italy.
We engineered an in vitro model of bioartificial 3D bone organoid consistent with an anatomical and vascular microenvironment common to mammalian flat and short bones. To achieve this, we chose the decellularized-decalcified matrix of the adult male rat scapula, implemented with the reconstruction of its intrinsic vessels, obtained through an original intravascular perfusion with polylevolactic (PLLA), followed by coating of the PLLA-fabricated vascularization with rat tail collagen. As a result, the 3D bone and vascular geometry of the native bone cortical and cancellous compartments was reproduced, and the rat tail collagen-PLLA biomaterial could in vitro act as a surrogate of the perivascular extracellular matrix (ECM) around the wall of the biomaterial-reconstituted cancellous vessels.
View Article and Find Full Text PDFMulti-scale vascularization strategy for 3D-bioprinted tissue using coaxial core-shell pre-set extrusion bioprinting and biochemical factors.
Int J Bioprint
April 2023
T&R Biofab, Siheung-si, Gyeonggi-do, Republic of Korea.
Three-dimensional bioprinting is a key technology in bioartificial organ production. However, production of bioartificial organs has significant limitations because it is hard to build vascular structures, especially capillaries, in printed tissue owing to its low resolution. As the vascular structure plays a critical role in delivering oxygen and nutrients to cells and removing metabolic waste, building vascular channels in bioprinted tissue is essential for bioartificial organ production.
View Article and Find Full Text PDFAn Engineered Living Intestinal Muscle Patch Produces Macroscopic Contractions that can Mix and Break Down Artificial Intestinal Contents.
Adv Mater
April 2023
Division of Pediatric Surgery, Departments of Surgery and Bioengineering, Stanford University School of Medicine, Stanford, CA, 94305, USA.
The intestinal muscle layers execute various gut wall movements to achieve controlled propulsion and mixing of intestinal content. Engineering intestinal muscle layers with complex contractile function is critical for developing bioartificial intestinal tissue to treat patients with short bowel syndrome. Here, the first demonstration of a living intestinal muscle patch capable of generating three distinct motility patterns and displaying multiple digesta manipulations is reported.
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