Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new aristolactam aristolactam-CV (4), together with 10 known compounds (5-14), were isolated from the rhizomes of Aristolochia championii. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All of the isolated compounds were evaluated for their cytotoxic activities against HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cell. Compound 1 exhibited significant cytotoxic activity against HCT-116, HepG2, BGC-823, and NCI-H1650, with IC values of 0.50, 7.37, 2.66, and 0.75μM, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fitote.2017.01.006 | DOI Listing |
Publication Analysis
Top Keywords
aristolochic acid
8
acid derivatives
8
hct-116 hepg2
8
hepg2 bgc-823
8
bgc-823 nci-h1650
8
derivatives rhizome
4
rhizome arisolochia
4
arisolochia championii
4
championii aristolochic
4
derivatives aristchamic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!