Calcium signaling plays an important role in cell survival by influencing mitochondria-related processes such as energy production and apoptosis. The endoplasmic reticulum (ER) is the main storage compartment for cell calcium (Ca; ~60-500μM), and the Ca released by the ER has a prompt effect on the homeostasis of the juxtaposed mitochondria. Recent findings have highlighted a close connection between ER redox and Ca signaling that is mediated by Ca-handling proteins. This paper describes the redox-regulated mediators and mechanisms that orchestrate Ca signals from the ER to mitochondria.
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| http://dx.doi.org/10.1016/j.jmb.2017.01.017 | DOI Listing |
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