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Preparation and Evaluation of the Gel-forming Chitosan Hydrogels for Nasal Delivery of Morphine in a Single Unit dose in Rats to Enhance the Analgesic Responses.
Curr Drug Deliv
May 2024
Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Introduction: In this study, an gel-forming chitosan hydrogel was prepared with the use of glutamate salt of chitosan (Ch-Ga), β-glycerophosphate (Gp), and morphine (Mor). The paper is focused on physicochemical properties and analgesic effects of the prepared chitosan hydrogel.
Method: The thermosensitive properties of prepared chitosan hydrogel were evaluated during the different temperatures and times.
Intraoperative hydromorphone decreases postoperative pain: an instrumental variable analysis.
Br J Anaesth
July 2023
Department of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, CA, USA. Electronic address:
Background: Intraoperative administration of short-acting opioids might lead to increased postoperative pain and opioid requirements. There are few data describing the effects of intermediate-duration opioids such as hydromorphone on these outcomes. We have previously shown that a switch from a 2 mg to a 1 mg vial of hydromorphone was associated with decreased intraoperative dose administration.
View Article and Find Full Text PDFSensitivity of a fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations.
Pharmacol Biochem Behav
November 2022
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Division of Therapeutics and Medical Consequences, National Institute on Drug Abuse, North Bethesda, MD, USA. Electronic address:
Recent studies have shown that social interaction can serve as an alternative reinforcer to opioid self-administration under a choice context in rats. However, additional parametric studies are needed to evaluate the sensitivity of opioid-vs.-social interaction procedures relative to more established opioid-vs.
View Article and Find Full Text PDFThe impact of reducing opioid unit dose quantities on perioperative utilization and pain scores for laparoscopic cholecystectomies.
Pain Manag
October 2022
Department of Anesthesiology, University of Tennessee Medical Center, Knoxville, TN 37920, USA.
At our institution, reductions to hydromorphone and fentanyl unit dose quantities provided us with a unique opportunity to study opioid utilization. A retrospective study examining effects of changes in opioid unit dose on intra-operative and postoperative opioid utilization in patients who underwent laparoscopic cholecystectomy. The study included three arms: the predosage change (n = 254), fentanyl only change group (n = 102) and the postdosage change arm (n = 254).
View Article and Find Full Text PDFMargin of safety of extended-duration transdermal buprenorphine solution following multiple-dose administrations to cats.
J Vet Pharmacol Ther
July 2022
Nexcyon Pharmaceuticals, Inc., Madison, Wisconsin, USA.
Transdermal buprenorphine solution (TBS) is approved for the control of postoperative pain in cats where a single preoperative dose provides 4 days of analgesia. It is administered as a unit dose of 8 mg to cats weighing 1.2-3 kg and 20 mg to cats weighing to >3-7.
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