The purpose of this study is to construct bone tissue engineering scaffold with high porosity, good mechanical properties, and biological activities. Bioactive glass/gelatin composite scaffolds with different amounts of tetrapod zinc oxide whiskers were produced. The morphology, mechanical properties and in vitro bioactivity of the composite scaffolds were investigated. Results showed that, the composite scaffolds had open pores with a high degree of interconnectivity, and the porosity was higher than 80%. With the amount of ZnO whiskers increased, the mechanical properties of scaffolds increased. However, the reinforcing effect began to decrease when the addition is higher than 2wt%, which was resulted by the aggregation of the ZnO whiskers. In vitro test showed that, the composite scaffolds processed good biodegradability, and in vitro apatite-forming ability. The release of zinc ions retarded the growth of the HCA, so the HCA deposited on the scaffolds with ZnO was amorphous and worm-like. Furthermore, the composite scaffolds had good biocompatibility assessed by in vitro cell tests using rMSCs. All results are promising for the application of the composite scaffolds in bone repair.
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