N,N-Dimethylanilines were coupled with α-azidochalcones using visible-light driven Ru(bpy)(PF) catalyzed photocascade continuous flow microfluidic approach that involves the creation of one C-C and two C-N new bonds. The reaction involves dual photocatalysis ensuing two sp C-H bond functionalization of N,N-dimethylanilines. To explore the scope of the reaction, 20 different 1,3-diazabicyclo[3.1.0]hexanes were synthesized in good yields (55-71%).
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| http://dx.doi.org/10.1021/acs.joc.6b02932 | DOI Listing |
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