Connectionist accounts of quasiregular domains, such as spelling-sound correspondences in English, represent exception words (e.g., pint) amid regular words (e.g., mint) via a graded "warping" mechanism. Warping allows the model to extend the dominant pronunciation to nonwords (regularization) with minimal interference (spillover) from the exceptions. We tested for a behavioral marker of warping by investigating the degree to which participants generalized from newly learned made-up words, which ranged from sharing the dominant pronunciation (regulars), a subordinate pronunciation (ambiguous), or a previously nonexistent (exception) pronunciation. The new words were learned over 2 days, and generalization was assessed 48 hr later using nonword neighbors of the new words in a tempo naming task. The frequency of regularization (a measure of generalization) was directly related to degree of warping required to learn the pronunciation of the new word. Simulations using the Plaut, McClelland, Seidenberg, and Patterson (1996) model further support a warping interpretation. These findings highlight the need to develop theories of representation that are integrally tied to how those representations are learned and generalized. (PsycINFO Database Record
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Ann Neurol
January 2025
Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Objective: The Clarity AD phase III trial showed that lecanemab reduced amyloid markers in early Alzheimer's disease (AD) and resulted in less decline on measures of cognition and function than placebo. Herein, we aimed to characterize amyloid-β (Aβ) protofibril (PF) captured by lecanemab in human cerebrospinal fluid (CSF) from living participants with different stages in AD, which enable an enhanced understanding of the dynamic changes of lecanemab-associated Aβ-PF (Lec-PF) in vivo.
Methods: We newly developed a unique and highly sensitive immunoassay method using lecanemab that selectively captures Lec-PF.
Background: Complex educational challenges emerge during Doctor of Philosophy (PhD) dissertation research, yet many newly hired faculty receive little preparation for the role of dissertation supervisor. The intensity and rigor of dissertation supervision are not reflected in workload calculations based on enrollments or clock hours. New faculty have few venues beyond personal experience to learn the challenges that supervision entails.
View Article and Find Full Text PDFAttention-deficit/hyperactivity disorder (ADHD) is a treatable pediatric condition, but children with racial-ethnic minority backgrounds often do not receive timely or consistent treatment. Understanding how systemic racism impacts care and learning from families of color about their experiences can provide critical insights for improving clinical practice and engaging patients equitably in ADHD care. We interweave a mother's experience navigating ADHD care for her son with commentary from an interprofessional team about what clinicians can do for families to reduce the impact of systemic racism on care.
View Article and Find Full Text PDFInt J Clin Health Psychol
December 2024
First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Objective: College students with subclinical depression often experience sleep disturbances and are at high risk of developing major depressive disorder without early intervention. Clinical guidelines recommend non-pharmacotherapy as the primary option for subclinical depression with comorbid sleep disorders (sDSDs). However, the neuroimaging mechanisms and therapeutic responses associated with these treatments are poorly understood.
View Article and Find Full Text PDFBMC Med Imaging
January 2025
Department of Information and Communication Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
A bone fracture is a medical condition characterized by a partial or complete break in the continuity of the bone. Fractures are primarily caused by injuries and accidents, affecting millions of people worldwide. The healing process for a fracture can take anywhere from one month to one year, leading to significant economic and psychological challenges for patients.
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