N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines.

Chem Commun (Camb)

Laboratoire de Synthèse Organique, CNRS, Ecole Polytechnique, ENSTA ParisTech- UMR 7652, Université Paris-Saclay, 828 Bd des Maréchaux, 91128 Palaiseau, France.

Published: February 2017

The Ugi reaction has drawn considerable attention over the years leading to numerous libraries of heterocycles and various extensions changing the nature of the components of the coupling. We report here the use of nitric acid as carboxylic acids surrogates, displaying the first aminative Ugi-type reaction leading to nitramines.

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Source
http://dx.doi.org/10.1039/c6cc10288cDOI Listing

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