AI Article Synopsis
- The study looked at the effectiveness and safety of preoperative chemoradiotherapy (NACR) in patients with Stage II and III esophageal squamous cell carcinoma.
- A total of 86 patients were treated between 2004 and 2014, with common side effects including leukopenia and anorexia, but overall, the treatment did not result in high mortality rates.
- The 5-year overall survival rate was 51.0%, with significantly better outcomes for Stage II patients compared to Stage III patients, indicating NACR may enhance survival and reduce tumor stage before surgery.
Article Abstract
Background: The goal of this retrospective study was to investigate the efficacy and safety of preoperative chemoradiotherapy( NACR)in patients with Stage II or Stage III esophageal squamous cell carcinoma(SCC).
Methods: Between 2004 and 2014, a total of 86 patients underwent surgical resection in conjunction with NACR for esophageal SCC at our institute. Thirty-one patients(36.0%)had Stage II disease and 55 patients(64.0%)had Stage III disease.
Results: The median age was 64(43-81)years. A total of 78 patients received the full NACR regimen. The most common major Grade 3 hematologic toxic effects of NACR were leukopenia and neutropenia(48 cases), while the most common major Grade 3 non-hematologic toxic effect was anorexia(12 cases). One patient died in the hospital and no patients died within 30 days after surgery. A pathological complete response was achieved in 23 cases. Pathological staging(number of cases)was Stage 0(23), Stage I (8), Stage II (28), Stage III (25), and Stage IV (2). The 5-year overall survival rate(OS)was 51.0%, and was 83.2% in Stage II patients and 29.9% in Stage III patients.
Conclusion: Preoperative NACR is safe and may improve OS and downstaging rates in patients with esophageal SCC.
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