How safe are the ramp terminals of a diverging diamond interchange (DDI)? This paper answered this question using data from DDI sites in Missouri. First, crash prediction models for ramp terminals for different crash severities were developed. These models were then utilized in the Empirical Bayes (EB) evaluation of DDI ramp terminals. Due to inconsistencies in crash reporting for freeways in Missouri, individual crash reports were reviewed to properly identify ramp terminal crashes. A total of 13,000 crash reports were reviewed for model development and EB evaluation. The study found that the DDI ramp terminals were safer than the conventional diamond signalized terminals. The DDI ramp terminals experienced 55% fewer fatal and injury crashes, 31.4% fewer property damage only crashes, and 37.5% fewer total crashes.
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http://dx.doi.org/10.1016/j.aap.2017.01.014 | DOI Listing |
Cell Rep
January 2025
Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:
Understanding how corticostriatal circuits mediate behavioral selection and initiation in a naturalistic setting is critical to understanding behavior choice and execution in unconstrained situations. The central striatum (CS) is well poised to play an important role in these spontaneous processes. Using fiber photometry and optogenetics, we identify a role for CS in grooming initiation.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:
The chemokine CXCL12 and its two cognate receptors-CXCR4 and ACKR3-are key players in various homeostatic and pathophysiological processes, including embryonic development, autoimmune diseases, tissue repair, and cancer. Recent reports identified an interaction of CXCR4 and ACKR3 with receptor activity-modifying proteins (RAMPs), and RAMP3 has been shown to facilitate ACKR3's recycling properties. Yet, the functional effects of RAMPs on the CXCL12 signaling axis remain largely elusive.
View Article and Find Full Text PDFAccid Anal Prev
February 2025
Graduate Research Assistant, Department of Civil and Environmental Engineering Auburn University, Auburn, AL, 36849, USA. Electronic address:
This study addresses the issue of wrong-way driving (WWD) incidents at partial cloverleaf (parclo) interchange terminals in the United States. These incidents are a safety concern, often attributed to geometric design features and inadequate traffic control devices (TCDs). While previous research has acknowledged the significance of parclo interchanges as common initial entry points for WWD crashes, few studies have comprehensively quantified the impact of TCDs and design features on recurring WWD incidents.
View Article and Find Full Text PDFbioRxiv
August 2024
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Endocr Metab Immune Disord Drug Targets
July 2024
R&D Unit, HS Hospital Service SpA, Aprilia, Italy.
Ultrasound-guided percutaneous Microwave Thermoablation (MWA) is an increasingly popular minimally invasive therapy for the treatment of benign thyroid nodules due to its remarkable heating velocity and resilience to heat sinking. We present a cohort of 26 patients (17 F, 9M, mean age 56.2yy) with 20 goiters (mean volume 34.
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