The Rational Addiction (RA) model is increasingly often estimated using individual level panel data with mixed results; in particular, with regard to the implied rate of time discount. This paper suggests that the odd values of the rate of discount frequently found in the literature may in fact be a consequence of the saddle-point dynamics associated with individual level inter-temporal optimization problems. We report the results of Monte Carlo experiments estimating RA-type difference equations that seem to suggest the possibility that the presence of both a stable and an unstable root in the dynamic process may create serious problems for the estimation of RA equations.
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http://dx.doi.org/10.1016/j.jhealeco.2016.12.005 | DOI Listing |
Expert Opin Drug Saf
January 2025
Department of ADR Monitoring, Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, Guangdong, China.
Background: The aims of this study were to promote the rational use and supervision of dextromethorphan (DM). This study analyzed serious adverse events such as addiction and mental disorders caused by DM in Shenzhen and the behavioral characteristics of people suspected of abusing DM on the Internet.
Methods: Adverse drug reaction/event (ADR/E) reports from 2017 to 2023 were extracted from the National Pharmaceutical Adverse Reaction Monitoring System database.
Sci Rep
January 2025
Düzce University, Düzce, Turkey.
The present study examined the relationships between the levels of online game addiction among university students who play online games and their life satisfaction, emotional schemas, and demographic characteristics (gender and age). Additionally, structural equation modelling was conducted to examine the mediating effect of emotional schemas in the relationship between online gaming addiction and life satisfaction. The participants of the study consist of 549 university students who are enrolled in university and play online games.
View Article and Find Full Text PDFNat Commun
December 2024
Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.
The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. Extracellular adenosine alleviates pain by activating the adenosine A1 receptor (A1R).
View Article and Find Full Text PDFEur J Med Chem
February 2025
Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, China. Electronic address:
FMS-like tyrosine receptor kinase 3 (FLT3) mutations, the most common genetic alterations found in acute myeloid leukemia (AML) patients, have been pursued as an ideal drug discovery target for the AML therapy. Taking compound 2 as lead, a series of pyridine derivatives bearing 1,2,3-triazole moiety were rationally designed and synthesized. The bioassays confirmed that these derivatives exerted potent antileukemia effects, and compound 12y was found to be the most potent one.
View Article and Find Full Text PDFBMC Public Health
December 2024
PluSport, Umbrella Organization of Swiss Disabled Sports, Volketswil, Switzerland.
Background: The positive influence of physical activities on a person's physical and mental health has been proven many times. These findings were implemented in the regular exercise therapy offered within psychiatric hospitals in Switzerland. However, after leaving a psychiatric hospital, there are insufficient opportunities for individuals with psychiatric disorders to engage in sports.
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