AI Article Synopsis
- Withania somnifera extracts have anti-cancer, anti-inflammatory, and antioxidative properties that can affect mitochondrial function by increasing oxidative stress.
- Recent studies suggest that 'priming' with these extracts can enhance cancer cell death, specifically in HT-29 colon cells when combined with the chemotherapy drug cisplatin.
- The mechanism behind this 'priming' effect involves increased reactive oxygen species (ROS) and is selective, as it does not occur in non-cancerous cells.
Article Abstract
Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of 'priming' was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271386 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170917 | PLOS |
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