Photomediated Larvicidal Activity of Pheophorbide a against Cercaria Larvae of .

Fasciolosis is a parasitic disease caused by . The freshwater snail is the intermediate host of which cause endemic fasciolosis in the northern part of India. To investigate larvicidal activity of pure and laboratory extracted pheophorbide a (Pa) against cercaria larvae of , data were analyzed in different spectra of visible light, sunlight, and laboratory conditions. Photostimulation of chlorophyll derivative pheophorbide a (Pa) caused time and concentration dependent larvicidal activity against cercaria larvae of . Larvicidal activity of pure Pa under 650 nm and 400-650 nm (8 h LC 0.006 mg/10 mL) was more pronounced than extracted Pa under same irradiations (650 nm LC 0.12 mg/10 mL, 400-650 nm LC 0.14 mg/10 mL). Lowest toxicity of pure (8 h LC 0.14 mg/10 mL) and extracted Pa (8 h LC 1.25 mg/10 mL) was noted under 400 nm. Pa was found to be toxic in laboratory conditions also. The results presented in this paper indicate that pheophorbide a possess potential larvicidal activity against larvae in different wavelengths of visible light, sunlight, and laboratory conditions.