Abstract: Phosphoethanolamine derivatives of the bacterial saccharide l--d--heptose have been prepared using a phosphoramidite-based coupling reaction at position 4 of a side-chain-protected 2,3--orthoester methyl heptoside and at position 3 of a 3,4-diol heptoside, respectively. Global deprotection afforded the corresponding 2-aminoethylphosphodiester derivatives as substrates for crystallographic and binding studies with lectins and antibodies targeting the inner core structure of bacterial lipopolysaccharides.
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| http://dx.doi.org/10.1007/s00706-016-1868-6 | DOI Listing |
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