Abstract: 2-Deoxy-D-ribose was converted to /-mixtures of methyl 3--acetyl- and methyl 3--benzoyl-2-deoxy-5-(-toluenesulfonyl)-D-ribofuranosides. These were reacted with boron trichloride to generate ribofuranosyl chlorides, which afforded precursors for tracers to image tumor hypoxia on substitution with salts of 2-nitroimidazole. The anomeric ratio of the nucleosides was delicately influenced by the reaction conditions.
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