Stromal microenvironment in type VII collagen-deficient skin: The ground for squamous cell carcinoma development.

Matrix Biol

Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy. Electronic address:

Published: November 2017

AI Article Synopsis

  • Recessive dystrophic epidermolysis bullosa (RDEB) is a skin condition linked to mutations in type VII collagen, leading to severe blistering, chronic wounds, and subsequent scarring.
  • Patients with severe RDEB face a high risk of developing squamous cell carcinomas (SCC), which are major causes of mortality.
  • Recent studies show that RDEB wounds have increased inflammation and specific cell activity that creates a tumor-promoting environment, suggesting potential therapeutic targets to reduce fibrosis and cancer risk.

Article Abstract

Recessive dystrophic epidermolysis bullosa (RDEB) is a skin fragility disease caused by mutations that affect the function and/or the amount of type VII collagen (C7), the major component of anchoring fibrils. Hallmarks of RDEB are unremitting blistering and chronic wounds leading to tissue fibrosis and scarring. Nearly all patients with severe RDEB develop highly metastatic squamous cell carcinomas (SCC) which are the main cause of death. Accumulating evidence from a murine RDEB model and human RDEB cells demonstrates that lack of C7 also directly alters the wound healing process. Non-healing RDEB wounds are characterized by increased inflammation, high transforming growth factor-β1 (TGF-β1) levels and activity, and are heavily populated by myofibroblasts responsible for enhanced fibrogenesis and matrix stiffness. These changes make the RDEB stroma a microenvironment prone to cancer initiation, where cells with features of cancer-associated fibroblasts are found. Here, we discuss recent knowledge on microenvironment alterations in RDEB, highlighting possible therapeutic targets to prevent and/or delay fibrosis and SCC development.

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http://dx.doi.org/10.1016/j.matbio.2017.01.002DOI Listing

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