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Investigation of an Outbreak of Equine Herpesvirus-1 Myeloencephalopathy in a Population of Aged Working Equids.
Viruses
December 2024
Carson Valley Large Animal Clinic, Gardnerville, NV 89460, USA.
The objective of this study was to describe an outbreak of equine herpesvirus-1 myeloencephalopathy (EHM) in a population of aged equids. The outbreak was linked to the introduction of five healthy non-resident horses 15 days prior to the first case of acute recumbency. This fulminant EHM outbreak was predisposed by the grouping of the 33 unvaccinated animals in two large pens with shared water and feed troughs.
View Article and Find Full Text PDF[Single-center study of COVID-19 in patients with chronic lymphocytic leukemia].
Zhonghua Xue Ye Xue Za Zhi
October 2024
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China Department of Hematology, The Affiliate Suqian First People's Hospital of Nanjing Medical University, Suqian Branch of Jiangsu Provincial People's Hospital, Suqian 223999, China.
To investigate the vaccination status, characteristics and prognosis of patients suffering from a combination of COVID-19 and chronic lymphocytic anemia (CLL) in China. Clinical data of 328 patients with chronic lymphocytic leukemia (CLL) who were first diagnosed with COVID-19 and treated in the Department of Hematology of Jiangsu Provincial People's Hospital between November 2022 and February 2023 were retrospectively analyzed. Univariate and multivariate analysis of data of patients with severe/critical COVID-19 were conducted by applying the binary logistic regression model.
View Article and Find Full Text PDFDose, exposure, and treatment regimen of intravenous immunoglobulin G in multifocal motor neuropathy.
Front Neurol
November 2024
Global Clinical Sciences, Takeda Development Center Americas, Inc., Cambridge, MA, United States.
Introduction: Intravenous immunoglobulin (IVIG) is the only approved treatment for multifocal motor neuropathy (MMN), a rare, chronic, immune-mediated demyelinating neuropathy. There is a significant gap in understanding of the role of serum immunoglobulin G (IgG) levels in the efficacy of IVIG in affected patients. We aimed to characterize the interplay between dose and exposure of IVIG and the effects of patient factors on individual variabilities.
View Article and Find Full Text PDFOutcomes of X-Linked Agammaglobulinaemia Patients.
J Clin Immunol
November 2024
Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.
Background: X-linked agammaglobulinaemia (XLA), caused by mutations in BTK, is characterised by low or absent peripheral CD19 + B lymphocytes and agammaglobulinaemia. The mainstay of treatment consists of immunoglobulin replacement therapy (IgRT). As this cannot fully compensate for the immune defects in XLA, patients may therefore continue to be at risk of complications.
View Article and Find Full Text PDFImmunoglobulin therapies for primary immunodeficiency diseases (part 2): considerations for dosing strategies.
Immunotherapy
October 2024
Clinical Pharmacology & Early Clinical Development, Takeda Development Center Americas, Inc., Cambridge, MA 02142, USA.
Article Synopsis
- - Immunoglobulin G (IgG) dosing for primary immunodeficiency diseases (PIDs) is personalized, taking into account individual patient experiences, clinical status, and physician input.
- - Regular monitoring of serum IgG levels is crucial for both diagnosing PIDs and adjusting IgG treatment plans, and this process should not be done alone but as part of a broader care strategy.
- - The review explores current and future IgG dosing strategies, considering distinct patient groups, such as those new to immunoglobulin therapy and those transitioning between intravenous (IVIG) and subcutaneous (SCIG) administration.
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