Background: Measuring the evolutionary rate of reproductive isolation is essential to understanding how new species form. Tempo calculations typically rely on fossil records, geological events, and molecular evolution analyses. The speed at which genetically-based hybrid mortality arises, or the "incompatibility clock", is estimated to be millions of years in various diploid organisms and is poorly understood in general. Owing to these extended timeframes, seldom do biologists observe the evolution of hybrid mortality in real time.
Results: Here we report the very recent spread and fixation of complete asymmetric F hybrid mortality within eight years of laboratory maintenance in the insect model Nasonia. The asymmetric interspecific hybrid mortality evolved in an isogenic stock line of N. longicornis and occurs in crosses to N. vitripennis males. The resulting diploid hybrids exhibit complete failure in dorsal closure during embryogenesis.
Conclusion: These results comprise a unique case whereby a strong asymmetrical isolation barrier evolved in real time. The spread of this reproductive isolation barrier notably occurred in a small laboratory stock subject to recurrent bottlenecks.
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http://dx.doi.org/10.1186/s12862-017-0879-1 | DOI Listing |
Anal Bioanal Chem
March 2025
Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China.
Cancer remains the leading cause of death worldwide, and early detection can significantly reduce patient mortality. Circulating tumor cells (CTCs), which are tumor cells shed from the primary tumor and transported to distant sites through the bloodstream, are key biomarkers for cancer diagnosis and contain critical information reflecting the primary tumor, making them important for monitoring cancer progression. Microfluidic chips utilizing a purely physical capture technique based on the size and deformability differences between CTCs and other blood cells have proven to be effective in capturing CTCs.
View Article and Find Full Text PDFMalar J
March 2025
US President's Malaria Initiative Evolve Project, Abt Associates, Rockville, MD, USA.
Background: Information on the status of insecticide resistance in malaria vectors is critical for implementing effective malaria vector control. The Sierra Leone National Malaria Control Programme, in collaboration with the PMI VectorLink project, assessed the resistance status to insecticides commonly used in public health, and associated resistance mechanisms in Anopheles gambiae, the main vector of malaria in Sierra Leone.
Methods: The susceptibility of An.
NPJ Digit Med
March 2025
Departments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Low-dose computed tomography attenuation correction (CTAC) scans are used in hybrid myocardial perfusion imaging (MPI) for attenuation correction and coronary calcium scoring, and contain additional anatomic and pathologic information not utilized in clinical assessment. We seek to uncover the full potential of these scans utilizing a holistic artificial intelligence (AI) approach. A multi-structure model segmented 33 structures and quantified 15 radiomics features in each organ in 10,480 patients from 4 sites.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Statistics and Data Science, Jahangirnagar University, Dhaka, 1342, Bangladesh.
Heatwaves pose a significant threat to environmental sustainability and public health, particularly in vulnerable regions and rapidly growing cities. They cause water shortages, stress on plants, and an overall drying out of landscapes, reducing plant growth-the basis of energy production and the food chain. Accurate heatwave forecasting is crucial for early warning systems, public health interventions, and disaster preparedness strategies, reducing heat-related mortality risk through modeling and evaluation of warnings.
View Article and Find Full Text PDFBMJ Open
March 2025
Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University of Halle Wittenberg Faculty of Medicine, Halle (Saale), Germany.
Introduction: Oesophageal cancer is the seventh most frequently diagnosed cancer and the sixth leading cause of cancer-related deaths worldwide. Oesophagectomy remains the main curative treatment option. The effect of different surgical approaches (completely open, hybrid, completely minimally invasive and robot-assisted) on patients undergoing thoracoabdominal oesophagectomy (Ivor-Lewis's procedure) for oesophageal cancer is evaluated, focusing on overall survival, postoperative mortality and morbidity.
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