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Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers. | LitMetric

Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers.

Molecules

Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Nanning 530008, Guangxi, China.

Published: January 2017

A series of novel myrtenal derivatives bearing 1,2,4-triazole moiety were designed and synthesized by multi-step reactions in an attempt to develop potent antifungal agents. Their structures were confirmed by using UV-vis, FTIR, NMR, and ESI-MS analysis. Antifungal activity of the target compounds was preliminarily evaluated by the in vitro method against f. sp. , , , , and at 50 µg/mL. Compounds (R = -Pr), (R = -NO₂ Bn), and (R = Et) exhibited excellent antifungal activity against with inhibition rates of 98.2%, 96.4%, and 90.7%, respectively, showing better or comparable antifungal activity than that of the commercial fungicide azoxystrobin with a 96.0% inhibition rate, which served as a positive control.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155697PMC
http://dx.doi.org/10.3390/molecules22020193DOI Listing

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