Objective/methods: DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter methylation along with mRNA profiles in paired samples of human subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) from non-obese obese individuals.
Results: We identified negatively correlated methylation and expression of several obesity-associated genes in our discovery dataset and replicated in two independent cohorts. Further, we identified six adipose tissue depot-specific genes (, , , , , and ). The effects were further supported in additional independent cohorts. Our top hits might play a role in adipogenesis and differentiation, obesity, lipid metabolism, and adipose tissue expandability. Finally, we show that methylation of directly represses gene expression.
Conclusions: Taken together, our data show distinct tissue specific epigenetic alterations which associate with obesity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220399 | PMC |
| http://dx.doi.org/10.1016/j.molmet.2016.11.003 | DOI Listing |
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