AI Article Synopsis
- The study analyzes how risk factors for peripheral artery disease (PAD) differ by age in patients with systemic lupus erythematosus (SLE).
- 216 SLE patients were divided into three age groups, and various risk factors were identified through statistical analysis.
- Results showed that younger patients had risk factors like antiphospholipid antibodies and glucocorticoids, while older patients showed trends related to hypertension and hypercholesterolemia, indicating that age influences PAD risk factors.
Article Abstract
Objective: To analyse the differential influence of risk factors of peripheral artery disease (PAD) according to age in patients with SLE.
Methods: 216 patients from the Lupus-Cruces cohort were divided in three age groups: ≤34 years, 35-49 years and ≥50 years. A low ankle-brachial index defined PAD. Significant variables were identified by univariant and multivariant analysis in each age group.
Results: Different factors were identified in different age groups: antiphospholipid antibodies/antiphospholipid syndrome and glucocorticoids in patients ≤34 years; in patients 35-49 years old, hypertension was the only statistically significant predictor, although a trend was observed for fibrinogen levels; a trend was observed for hypercholesterolaemia in those ≥50 years.
Conclusions: Age may modulate the influence of risk factors for PAD in patients with SLE.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255560 | PMC |
| http://dx.doi.org/10.1136/lupus-2016-000190 | DOI Listing |
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