Background: This meta-analysis aimed to determine whether extracorporeal cardiopulmonary resuscitation (ECPR), compared with conventional cardiopulmonary resuscitation (CCPR), improves outcomes in adult patients with cardiac arrest (CA).
Data Resources: PubMed, EMBASE, Web of Science, and China Biological Medicine Database were searched for relevant articles. The baseline information and outcome data (survival, good neurological outcome at discharge, at 3-6 months, and at 1 year after CA) were collected and extracted by two authors. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using Review Manager 5.3.
Results: In six studies 2 260 patients were enrolled to study the survival rate to discharge and long-term neurological outcome published since 2000. A significant effect of ECPR was observed on survival rate to discharge compared to CCPR in CA patients ( 2.37, 95% 1.63-3.45, <0.001), and patients who underwent ECPR had a better long-term neurological outcome than those who received CCPR ( 2.79, 95% 1.96-3.97, <0.001). In subgroup analysis, there was a significant difference in survival to discharge favoring ECPR over CCPR group in OHCA patients ( 2.69, 95% 1.48-4.91, =0.001). However, no significant difference was found in IHCA patients ( 1.84, 95% 0.91-3.73, =0.09).
Conclusion: ECPR showed a beneficial effect on survival rate to discharge and long-term neurological outcome over CCPR in adult patients with CA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263037 | PMC |
| http://dx.doi.org/10.5847/wjem.j.1920-8642.2017.01.001 | DOI Listing |
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