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Successful treatment of acrodermatitis continua of Hallopeau coexisting with generalized pustular psoriasis with spesolimab: a case report.
Front Immunol
March 2024
Department of Dermatovenerology, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- - Generalized pustular psoriasis (GPP) is a rare, painful skin condition marked by sterile pustules and lacks standardized treatment options; biologics have been used with mixed results.
- - Acrodermatitis continua of Hallopeau (ACH) is a severe variant of pustular psoriasis that is difficult to treat, and it shares a common pathogenic mechanism with GPP involving the IL-36 signaling axis.
- - A case study of an Asian patient with a long history of both GPP and ACH showed significant improvement in skin and nail lesions after receiving spesolimab, suggesting its potential effectiveness for treating ACH in patients with GPP.
Epidemiological survey of patients with pustular psoriasis in the Japanese Society for Psoriasis Research from 2017 to 2020.
J Dermatol
January 2023
Department of Dermatology, Jichi Medical University, Shimotsuke, Japan.
The Japanese Society for Psoriasis Research (JSPR) has been conducting annual epidemiological surveys of patients with pustular psoriasis in Japan since 2017. This study aimed to conduct a recent epidemiological analysis of patients with pustular psoriasis who were enrolled in the JSPR from 2017 to 2020. A total of 291 patients from 131 medical institutions were enrolled, of which 47.
View Article and Find Full Text PDFTargeting IL-17A for the treatment of pustular psoriasis: a comprehensive review.
Expert Opin Biol Ther
December 2022
Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
Introduction: Pustular psoriasis (PP) is a rare subtype of psoriasis. Overall, the growing evidence - in particular for acute generalized PP (GPP) - supports that it is a separate entity with a specific pathogenetic pathway. Interleukin (IL)-17/T-helper 17 (Th17) axis involvement may play an important role in the pathophysiology of PP.
View Article and Find Full Text PDFPustular Psoriasis: A Narrative Review of Recent Developments in Pathophysiology and Therapeutic Options.
Dermatol Ther (Heidelb)
December 2021
Department of Dermatology, Temple University School of Medicine, Philadelphia, PA, USA.
Article Synopsis
- * Diagnosis can be difficult due to its rarity and the lack of established, evidence-based treatments, often leading to management strategies borrowing from standard plaque psoriasis therapies.
- * Recent advances in understanding its causes have opened the door for new treatment options, particularly biologic therapies, with promising results from targeted therapies like spesolimab that inhibit the IL-36 pathway.
Treatment of acrodermatitis continua of Hallopeau: A case series of 39 patients.
J Dermatol
September 2020
Department of Dermatology, Venereology and Allergology, University Medical Center, Göttingen, Germany.
Acrodermatitis continua of Hallopeau (ACH) is a rare chronic inflammatory skin disease. Treatment is extremely challenging and mostly based on empirics as there is only scarce evidence from case reports and few small case series. In this retrospective study, patients with ACH treated at five university medical centers were analyzed according to patient and disease characteristics and treatment experience.
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